Leg ulcers in sickle cell patients: management challenges

Sickle cell disease is an autosomal recessive hemoglobinopathy caused by an amino acid substitution from glutamic acid to valine in the beta hemoglobin chain. One of the common symptoms occurring in sickle cell patients are leg ulcers, which are notoriously painful, difficult to treat, and frequentl...

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Bibliographic Details
Published in:Chronic wound care management and research 2016-11, Vol.3, p.157-161
Main Authors: El Khatib, Arij, Hayek, Shady
Format: Article
Language:English
Subjects:
Disease prevention
Hemoglobin
Leg ulcers
leg wound
Pain
Patients
Pulmonary hypertension
Quality of life
Sickle cell anemia
Sickle cell disease
Sickle cell leg ulcer
Surgery
Wound healing
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Summary:Sickle cell disease is an autosomal recessive hemoglobinopathy caused by an amino acid substitution from glutamic acid to valine in the beta hemoglobin chain. One of the common symptoms occurring in sickle cell patients are leg ulcers, which are notoriously painful, difficult to treat, and frequently recurrent. These ulcers pose a therapeutic challenge with multiple modalities proposed for treatment, but with scarce evidence of efficacy of any single modality. Ulcer prevention, rigorous wound care, pain control, and surgery are the current mainstays of sickle cell leg ulcer treatment.
ISSN:2324-481X
2324-481X
DOI:10.2147/CWCMR.S85455