Water-Soluble Tomato Concentrate, a Potential Antioxidant Supplement, Can Attenuate Platelet Apoptosis and Oxidative Stress in Healthy Middle-Aged and Elderly Adults: A Randomized, Double-Blinded, Crossover Clinical Trial

• Published in: Nutrients 2022-08, Vol.14 (16), p.3374
• Main Authors: Tian, Zezhong, Li, Kongyao, Fan, Die, Gao, Xiaoli, Ma, Xilin, Zhao, Yimin, Zhao, Dan, Liang, Ying, Ji, Qiuhua, Chen, Yiting, Yang, Yan
• Format: Article
• Language: English
• Subjects: Adult; Adults; Aged; Antioxidants; Antioxidants - pharmacology; Apoptosis; Arteriosclerosis; Atherosclerosis; Blood platelets; Blood pressure; Cardiovascular disease; Cardiovascular diseases; Clinical trials; Collagen; Complications and side effects; Control; Cross-sectional studies; crossover clinical trial; Development and progression; Diet; Dietary Supplements; Double-Blind Method; Health aspects; Health risks; Humans; Ingredients; Membrane potential; Middle age; Middle Aged; Middle aged persons; Mitochondria; Older people; Oxidative Stress; Phosphatidylserine; Physiological aspects; Platelet aggregation; platelet apoptosis; Prevention; Product development; Questionnaires; Reactive oxygen species; Risk analysis; Risk factors; Solanum lycopersicum; Thrombosis; Tomato products; Tomatoes; Water - pharmacology; Water chemistry; water-soluble tomato concentrate
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu14163374

Increased oxidative stress and platelet apoptotic in middle-aged and elderly adults are important risk factors for atherosclerotic cardiovascular disease (ASCVD). Therefore, it is of great significance to control the oxidative stress and platelet apoptosis in middle-aged and elderly adults. Previous acute clinical trials have shown that water-soluble tomato concentrate (WSTC) from fresh tomatoes could exert antiplatelet benefits after 3 h or 7 h, but its effects on platelet apoptosis and oxidative stress are still unknown, especially in healthy middle-aged and elderly adults. This current study aimed to examine the efficacies of WSTC on platelet apoptosis and oxidative stress in healthy middle-aged and elderly adults via a randomized double-blinded placebo-controlled crossover clinical trial (10 weeks in total). A total of 52 healthy middle-aged and elderly adults completed this trial. The results showed that WSTC could increase the serum total antioxidant capacity levels (p < 0.05) and decrease the serum malondialdehyde levels (p < 0.05) after a 4-week WSTC supplementation in healthy middle-aged and elderly adults. Platelet endogenous reactive oxygen species generation (p < 0.05), mitochondrial membrane potential dissipation (p < 0.05) and phosphatidylserine exposure (p < 0.05) were attenuated. In addition, our present study also found that WSTC could inhibit platelet aggregation and activation induced by collagen or ADP after intervention (p < 0.05), while having no effects on adverse events (p > 0.05). The results suggest that WSTC can inhibit oxidative stress and its related platelet apoptosis, which may provide a basis for the primary prevention of WSTC in ASCVD.