Liquid Biopsies: Emerging role and clinical applications in solid tumours

• Published in: Translational oncology 2023-09, Vol.35, p.101716-101716, Article 101716
• Main Authors: Sisodiya, Sandeep, Kasherwal, Vishakha, Khan, Asiya, Roy, Bishnudeo, Goel, Anjana, Kumar, Sandeep, Arif, Nazneen, Tanwar, Pranay, Hussain, Showket
• Format: Article
• Language: English
• Subjects: cell-free DNA; circulating tumour cells; circulating tumour DNA; Liquid biopsies; solid tumours
• ISSN: 1936-5233; 1936-5233
• DOI: 10.1016/j.tranon.2023.101716

•Article have discussed need of liquid biopsy-based biomarker discovery for early diagnosis, treatment response, and disease prognosis.•Article have discussed about the types of liquid biopsies.•The article discusses the clinical utility of liquid biopsies for diagnostic, prognostic, and potential therapeutic purposes in solid tumors.•Article have discussed limitation and future prospects of liquid biopsies. Late detection and lack of precision diagnostics are the major challenges in cancer prevention and management. Biomarker discovery in specific cancers, especially at the pre-invasive stage, is vital for early diagnosis, positive treatment response, and good disease prognosis. Traditional diagnostic measures require invasive procedures such as tissue excision using a needle, an endoscope, and/or surgical resection which can be unsafe, expensive, and painful. Additionally, the presence of comorbid conditions in individuals might render them ineligible for undertaking a tissue biopsy, and in some cases, it is difficult to access tumours depending on the site of occurrence. In this context, liquid biopsies are being explored for their clinical significance in solid malignancies management. These non-invasive or minimally invasive methods are being developed primarily for identification of biomarkers for early diagnosis and targeted therapeutics. In this review, we have summarised the use and importance of liquid biopsy as significant tool in diagnosis, prognosis prediction, and therapeutic development. We have also discussed the challenges that are encountered and future perspective. [Display omitted]