Prevalence of postprandial hyperglycaemia in basal insulin-treated patients with type 2 diabetes mellitus with controlled fasting glycaemia and elevated glycosylated haemoglobin

To study the prevalence of postprandial hyperglycaemia (PPH) in type 2 diabetes mellitus (T2DM) patients treated with basal insulin, having fasting glucose  7.0% (53 mmol/mol). This was an observational prospective multicentric study conducted in Spain. During 2 weeks, patients recorded a 6-point se...

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Bibliographic Details
Published in:Diabetology and metabolic syndrome 2019-07, Vol.11 (1), p.59-59, Article 59
Main Authors: Tinahones, Francisco J, Molina-Vega, María, Parra-Barona, Juan, Flores-Le Roux, Juana, Gómez-Huelgas, Ricardo
Format: Article
Language:English
Subjects:
Blood glucose
Care and treatment
Diabetes mellitus
Diabetes therapy
Fasting
Glucose
Glycosylated hemoglobin
HbA1c
Health aspects
Hemoglobins
Hyperglycaemia
Hyperglycemia
Hypoglycemic agents
Insulin
Patient outcomes
Postprandial glucose
Risk factors
Statistics
Type 2 diabetes
Type 2 diabetes mellitus
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Summary:To study the prevalence of postprandial hyperglycaemia (PPH) in type 2 diabetes mellitus (T2DM) patients treated with basal insulin, having fasting glucose  7.0% (53 mmol/mol). This was an observational prospective multicentric study conducted in Spain. During 2 weeks, patients recorded a 6-point self-measured blood glucose profile (before and 2 h after eating) every 2 days. PPH was defined according to IDF and ADA guidelines (> 160 and > 180 mg/dL, respectively). We included 98 patients (males: 56.1%; mean age: 64.3 ± 10.4 years) who were treated with basal insulin for at least 1 year at stable doses in the last 2 months, 88.8% of them received concomitant oral antidiabetic drugs. Overall, 95.7% (95% CI 91.6-99.8) and 93.5% (95% CI 88.6-98.5) of patients showed ≥ 1 episode of PPH according to IDF and ADA criteria respectively. PPH was more frequently observed after lunch and dinner. The proportion of patients with ≥ 40% readings in range of PPH was 59.1% (95% CI 49.1-69.1) and 40.9% (95% CI 30.9-50.9), according to IDF and ADA criteria, respectively. PPH is very common and should be considered a priority target in basal insulin-treated T2DM patients with elevated HbA1c despite controlled fasting glucose.
ISSN:1758-5996
1758-5996
DOI:10.1186/s13098-019-0452-8