When is a target not a target?

Cells rely on prolyl hydroxylase enzymes to sense low levels of oxygen, but they might act on fewer targets than previously thought.

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Bibliographic Details
Published in:eLife 2019-09, Vol.8
Main Authors: Bersten, David C, Peet, Daniel J
Format: Article
Language:English
Subjects:
Amino acids
Anemia
Biochemistry and Chemical Biology
Cells (Biology)
Crick, Francis
Enzymes
Erythropoietin
Experiments
Hormones
Hydroxylation
Hypoxia
Insight
Neovascularization
Oxygen
Oxygen Sensors
oxygenase
Physiological aspects
Physiology
Procollagen-Proline Dioxygenase
Prolyl hydroxylase
Prolyl Hydroxylases
Proteins
Researchers
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Description
Summary:Cells rely on prolyl hydroxylase enzymes to sense low levels of oxygen, but they might act on fewer targets than previously thought.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.50585