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IL-6 and IL-8 in cerebrospinal fluid from patients with aseptic meningitis and bacterial meningitis: their potential role as a marker for differential diagnosis
Cytokines are molecules that act as mediators of immune response; cerebral spinal fluid (CSF) IL-6 is found in all meningeal inflammatory diseases, but IL-8 is associated with acute bacterial meningitis (ABM). A case control study was done to ascertain the discriminatory power of these cytokines in...
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| Published in: | The Brazilian journal of infectious diseases 2011-03, Vol.15 (2), p.156-158 |
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| cited_by | cdi_FETCH-LOGICAL-c473t-db21f0cf076681a610036e1b5fc86ad80747a23712460dd05022416980dc61433 |
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| cites | cdi_FETCH-LOGICAL-c473t-db21f0cf076681a610036e1b5fc86ad80747a23712460dd05022416980dc61433 |
| container_end_page | 158 |
| container_issue | 2 |
| container_start_page | 156 |
| container_title | The Brazilian journal of infectious diseases |
| container_volume | 15 |
| creator | Pinto Junior, Vitor Laerte Laerte Rebelo, Maria Cristina Gomes, Rachel Novaes de Assis, Edson Fernandes Castro-Faria-Neto, Hugo C. Bóia, Marcio Neves |
| description | Cytokines are molecules that act as mediators of immune response; cerebral spinal fluid (CSF) IL-6 is found in all meningeal inflammatory diseases, but IL-8 is associated with acute bacterial meningitis (ABM). A case control study was done to ascertain the discriminatory power of these cytokines in differentiating ABM from aseptic meningitis (AM); IL-6 and IL-8 CSF concentrations were tested through ELISA in samples collected from patients who underwent investigation for meningitis. Sixty patients, 18 with AM, nine with bacteriologic confirmed ABM and 33 controls, assisted in 2005 (MA and controls) and 2007 (ABM) were included. Differently from controls, IL-6 concentrations were increased both in MA and ABM patients (p |
| doi_str_mv | 10.1016/S1413-8670(11)70162-3 |
| format | article |
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A case control study was done to ascertain the discriminatory power of these cytokines in differentiating ABM from aseptic meningitis (AM); IL-6 and IL-8 CSF concentrations were tested through ELISA in samples collected from patients who underwent investigation for meningitis. Sixty patients, 18 with AM, nine with bacteriologic confirmed ABM and 33 controls, assisted in 2005 (MA and controls) and 2007 (ABM) were included. Differently from controls, IL-6 concentrations were increased both in MA and ABM patients (p<0.05). CSF IL-8 levels were higher in ABM than in AM and controls (p<0.05). Discriminatory power in ABM as assessed by the area under receiver operator (ROC) curve was 0.951 for IL-8, using a cut-off of 1.685ng/dL (100% of sensitivity and 94% of specificity). The CSF concentration of both IL-6 and IL-8 are increased in the presence of meningeal inflammation, IL-8 could be an important tool to differentiate ABM from AM.</description><identifier>ISSN: 1413-8670</identifier><identifier>EISSN: 1678-4391</identifier><identifier>DOI: 10.1016/S1413-8670(11)70162-3</identifier><identifier>PMID: 21503403</identifier><language>eng</language><publisher>Brazil: Elsevier Editora Ltda</publisher><subject>Adolescent ; Adult ; aseptic meningitis ; bacteria ; Bacterial meningitis ; Biomarkers - cerebrospinal fluid ; Case-Control Studies ; Child ; Child, Preschool ; CSF ; Cytokines ; Diagnosis ; Diagnosis, Differential ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; IL-6 ; IL-8 ; Infant ; Infant, Newborn ; inflammation meningitis ; Interleukin-6 - cerebrospinal fluid ; Interleukin-8 - cerebrospinal fluid ; Male ; Meningitis, Aseptic - cerebrospinal fluid ; Meningitis, Aseptic - diagnosis ; Meningitis, Bacterial - cerebrospinal fluid ; Meningitis, Bacterial - diagnosis ; Middle Aged ; Sensitivity and Specificity ; Young Adult</subject><ispartof>The Brazilian journal of infectious diseases, 2011-03, Vol.15 (2), p.156-158</ispartof><rights>2011 Elsevier Editora Ltda.</rights><rights>COPYRIGHT 2011 Contexto</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-db21f0cf076681a610036e1b5fc86ad80747a23712460dd05022416980dc61433</citedby><cites>FETCH-LOGICAL-c473t-db21f0cf076681a610036e1b5fc86ad80747a23712460dd05022416980dc61433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1413867011701623$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21503403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pinto Junior, Vitor Laerte Laerte</creatorcontrib><creatorcontrib>Rebelo, Maria Cristina</creatorcontrib><creatorcontrib>Gomes, Rachel Novaes</creatorcontrib><creatorcontrib>de Assis, Edson Fernandes</creatorcontrib><creatorcontrib>Castro-Faria-Neto, Hugo C.</creatorcontrib><creatorcontrib>Bóia, Marcio Neves</creatorcontrib><title>IL-6 and IL-8 in cerebrospinal fluid from patients with aseptic meningitis and bacterial meningitis: their potential role as a marker for differential diagnosis</title><title>The Brazilian journal of infectious diseases</title><addtitle>Braz J Infect Dis</addtitle><description>Cytokines are molecules that act as mediators of immune response; cerebral spinal fluid (CSF) IL-6 is found in all meningeal inflammatory diseases, but IL-8 is associated with acute bacterial meningitis (ABM). A case control study was done to ascertain the discriminatory power of these cytokines in differentiating ABM from aseptic meningitis (AM); IL-6 and IL-8 CSF concentrations were tested through ELISA in samples collected from patients who underwent investigation for meningitis. Sixty patients, 18 with AM, nine with bacteriologic confirmed ABM and 33 controls, assisted in 2005 (MA and controls) and 2007 (ABM) were included. Differently from controls, IL-6 concentrations were increased both in MA and ABM patients (p<0.05). CSF IL-8 levels were higher in ABM than in AM and controls (p<0.05). Discriminatory power in ABM as assessed by the area under receiver operator (ROC) curve was 0.951 for IL-8, using a cut-off of 1.685ng/dL (100% of sensitivity and 94% of specificity). The CSF concentration of both IL-6 and IL-8 are increased in the presence of meningeal inflammation, IL-8 could be an important tool to differentiate ABM from AM.</description><subject>Adolescent</subject><subject>Adult</subject><subject>aseptic meningitis</subject><subject>bacteria</subject><subject>Bacterial meningitis</subject><subject>Biomarkers - cerebrospinal fluid</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>CSF</subject><subject>Cytokines</subject><subject>Diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>IL-6</subject><subject>IL-8</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>inflammation meningitis</subject><subject>Interleukin-6 - cerebrospinal fluid</subject><subject>Interleukin-8 - cerebrospinal fluid</subject><subject>Male</subject><subject>Meningitis, Aseptic - cerebrospinal fluid</subject><subject>Meningitis, Aseptic - diagnosis</subject><subject>Meningitis, Bacterial - cerebrospinal fluid</subject><subject>Meningitis, Bacterial - diagnosis</subject><subject>Middle Aged</subject><subject>Sensitivity and Specificity</subject><subject>Young Adult</subject><issn>1413-8670</issn><issn>1678-4391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqFUt2K1DAULqK46-ojKAFB9KJr0qRJZ29kWfwZGPBCvQ6Z5GTmrG1Tkozi2_ioplN3dUGQXCSc8_0kOV9VPWX0nFEmX39igvG6k4q-ZOyVKqWm5veqUyZVVwu-YvfL-QZyUj1K6ZrSpqWCPqxOGtZSLig_rX6uN7UkZnSkHDqCI7EQYRtDmnA0PfH9AR3xMQxkMhlhzIl8x7wnJsGU0ZIBRhx3mDEdVbbGZohYmH8aFyTvASOZQi78uRdDD0WBGDKY-BUi8SESh94X7wXh0OzGkDA9rh540yd48ns_q768e_v56kO9-fh-fXW5qa1QPNdu2zBPradKyo4ZySjlEti29baTxnVUCWUarlgjJHWOtrRpBJOrjjormeD8rFovui6Yaz1FLDf7oYNBfSyEuNMmlgf3oL1vihyjqnVcNJyuAFTxp0o1nSyWRev5orUzBY6jDzkaO2Cy-pKX2YiuW82O5_9AleVgQBtG8Fjqdwgv_iLswfR5n0J_yBjGdBfYLkBb5pgi-Nv3MKrn9OhjevQcDc2YPqZHz7xnC286bAdwt6ybuBTAmwUAZRLfEKJOtmTCgsMINpevwv9Y_AI9ONGt</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>Pinto Junior, Vitor Laerte Laerte</creator><creator>Rebelo, Maria Cristina</creator><creator>Gomes, Rachel Novaes</creator><creator>de Assis, Edson Fernandes</creator><creator>Castro-Faria-Neto, Hugo C.</creator><creator>Bóia, Marcio Neves</creator><general>Elsevier Editora Ltda</general><general>Contexto</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>INF</scope><scope>DOA</scope></search><sort><creationdate>201103</creationdate><title>IL-6 and IL-8 in cerebrospinal fluid from patients with aseptic meningitis and bacterial meningitis: their potential role as a marker for differential diagnosis</title><author>Pinto Junior, Vitor Laerte Laerte ; 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cerebral spinal fluid (CSF) IL-6 is found in all meningeal inflammatory diseases, but IL-8 is associated with acute bacterial meningitis (ABM). A case control study was done to ascertain the discriminatory power of these cytokines in differentiating ABM from aseptic meningitis (AM); IL-6 and IL-8 CSF concentrations were tested through ELISA in samples collected from patients who underwent investigation for meningitis. Sixty patients, 18 with AM, nine with bacteriologic confirmed ABM and 33 controls, assisted in 2005 (MA and controls) and 2007 (ABM) were included. Differently from controls, IL-6 concentrations were increased both in MA and ABM patients (p<0.05). CSF IL-8 levels were higher in ABM than in AM and controls (p<0.05). Discriminatory power in ABM as assessed by the area under receiver operator (ROC) curve was 0.951 for IL-8, using a cut-off of 1.685ng/dL (100% of sensitivity and 94% of specificity). The CSF concentration of both IL-6 and IL-8 are increased in the presence of meningeal inflammation, IL-8 could be an important tool to differentiate ABM from AM.</abstract><cop>Brazil</cop><pub>Elsevier Editora Ltda</pub><pmid>21503403</pmid><doi>10.1016/S1413-8670(11)70162-3</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1413-8670 |
| ispartof | The Brazilian journal of infectious diseases, 2011-03, Vol.15 (2), p.156-158 |
| issn | 1413-8670 1678-4391 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_ff20741075d342309ee7db20772861b5 |
| source | ScienceDirect Journals; SciELO |
| subjects | Adolescent Adult aseptic meningitis bacteria Bacterial meningitis Biomarkers - cerebrospinal fluid Case-Control Studies Child Child, Preschool CSF Cytokines Diagnosis Diagnosis, Differential Enzyme-Linked Immunosorbent Assay Female Humans IL-6 IL-8 Infant Infant, Newborn inflammation meningitis Interleukin-6 - cerebrospinal fluid Interleukin-8 - cerebrospinal fluid Male Meningitis, Aseptic - cerebrospinal fluid Meningitis, Aseptic - diagnosis Meningitis, Bacterial - cerebrospinal fluid Meningitis, Bacterial - diagnosis Middle Aged Sensitivity and Specificity Young Adult |
| title | IL-6 and IL-8 in cerebrospinal fluid from patients with aseptic meningitis and bacterial meningitis: their potential role as a marker for differential diagnosis |
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