Identification of the Chinese Population That Can Benefit Most From Postprandial Lipid Testing: Validation of the Use of Oral Fat Tolerance Testing in Clinical Practice

• Published in: Frontiers in endocrinology (Lausanne) 2022-02, Vol.13, p.831435
• Main Authors: Hou, Xiaoyu, Song, An, Guan, Yunpeng, Tian, Peipei, Ren, Luping, Tang, Yong, Wang, Chao, Gao, Ling, Song, Guangyao, Xing, Xiaoping
• Format: Article
• Language: English
• Subjects: Adult; China - epidemiology; diabetes; dyslipidemia; Dyslipidemias - diagnosis; Endocrinology; Humans; Lipids; oral fat tolerance test; postprandial lipemia; Postprandial Period; triglyceride; Triglycerides
• ISSN: 1664-2392; 1664-2392
• DOI: 10.3389/fendo.2022.831435

Dyslipidemia has become increasingly prevalent in recent decades. Blood lipid concentrations are significantly influenced by diet; however, postprandial triglyceride concentration (PTG) is not often measured. PTG can reflect the risks of diabetes and cardiovascular disease, but not all individuals would benefit from PTG testing. The aim of the present study was to determine the PTG response in a Chinese cohort and identify who would benefit from diagnostic PTG measurement. A total of 400 Chinese adults were enrolled and underwent oral fat tolerance test (OFTT), which was well tolerated. The participants were assigned to groups according to their fasting triglyceride concentration to evaluate the usefulness of PTG testing. A PTG concentration > 2.5 mmol/L was defined as high (HPTG). Of the 400 participants, 78.9% showed an undesirable PTG response. Those with FTG ≥1.0 mmol/L had a delayed PTG peak and higher peak values. Seventy-five percent of those with 1.0 mmol/L ≤FTG