Dynamic thiol/disulfide homeostasis and oxidant status in patients with hypoparathyroidism

• Published in: Journal of medical biochemistry 2020-01, Vol.39 (2), p.231-239
• Main Authors: Or, Koca Arzu, Dağdeviren, Murat, Akkan, Tolga, Ateş, İhsan, Neşelioğlu, Salim, Erel, Özcan, Altay, Mustafa
• Format: Article
• Language: English
• Subjects: disulfide; hypoparathyroidism; Original Paper; paraoxonase; thiol; total antioxidant status; total oxidant status
• ISSN: 1452-8258; 1452-8266; 1452-8266
• DOI: 10.2478/jomb-2019-0036

In this study, we aimed at determining the dynamic thiol/disulfide homeostasis and oxidant balance, and investigating the relation of these parameters to the severity of the disease and the serum calcium levels. 55 patients with iatrogenic hypoparathyroidism follow-ups and 40 healthy volunteers were included in the study. The blood dynamic thiol/sulfide balance, Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Paraoxonase Enzyme Activity (PON) levels were measured in serum samples. In our study, it was found that the disulfide, disulfide/native thiol, disulfide/total thiol levels were higher in the hypoparathyroidism group. A negative correlation was found between 25-hydroxy vitamin D (25-OH vitamin D) and disulfide, disulfide/native thiol and disulfide/total thiol, and a positive correlation was found between native thiol and total thiol ratio; and the corrected calcium levels and PON levels were negatively correlated. Consequently, a change in favour of disulfide was found in the dynamic thiol-disulfide homeostasis in the hypoparathyroidism group in our study.