Bicarbonate ringer's solution could improve the intraoperative acid-base equilibrium and reduce hepatocellular enzyme levels after deceased donor liver transplantation: a randomized controlled study

Bicarbonate Ringer's (BR) solution is a direct liver and kidney metabolism-independent HCO buffering system. We hypothesized that BR solution would be more effective in improving acid-base equilibrium and more conducive to better liver function than Acetate Ringer's (AR) solution in conven...

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Published in:BMC anesthesiology 2023-12, Vol.23 (1), p.418-418, Article 418
Main Authors: Li, Qingkai, Liu, Ying, Wang, Yanan, Shan, Xin, Liu, Chunxiao, Li, Zhihua, Cao, Jinglin, Dou, Jian, Xu, Guanjie, Wang, Qiujun, Qie, Xiaojuan
Format: Article
Language:English
Subjects:
Acetates
Acetic acid
Acid-Base Equilibrium
Acid-base status
Acidosis
Acids
Adult
Anesthesia
Aspartate
Aspartate transaminase
Bicarbonate Ringer’s solution
Bicarbonates
Blood
Carbonates
Carcinoma, Hepatocellular
Clinical trials
Creatine
Crystalloid
Electrolytes
Enzymes
Hemodynamics
Hemoglobin
Humans
Isotonic Solutions
Kidneys
Liver
Liver function
Liver Neoplasms
Liver Transplantation
Liver transplants
Living Donors
Medical research
Metabolism
Metabolites
Patients
Physiology
Remifentanil
Renal function
Reperfusion
Ringer's Solution
Sodium
Sodium Bicarbonate
Surgery
Transaminase
Transplantation
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Summary:Bicarbonate Ringer's (BR) solution is a direct liver and kidney metabolism-independent HCO buffering system. We hypothesized that BR solution would be more effective in improving acid-base equilibrium and more conducive to better liver function than Acetate Ringer's (AR) solution in conventional orthotopic liver transplantation (OLT) patients. Sixty-nine adult patients underwent OLT. Patients in the bicarbonate and acetate groups received BR solution or AR solution as infused crystalloids and graft washing solution, respectively. The primary outcome was the effect on pH and base excess (BE) levels. The secondary outcome measures were the incidence and volume of intraoperative 5% sodium bicarbonate infusion and laboratory indicates of liver and kidney function. The pH and absolute BE values changed significantly during the anhepatic phase and immediately after transplanted liver reperfusion in the bicarbonate group compared with the acetate group (all P 
ISSN:1471-2253
1471-2253
DOI:10.1186/s12871-023-02383-8