Effects of prednisolone on 1,2‐O‐dilauryl‐rac‐glycero glutaric acid‐(60‐methylresorufin) ester‐lipase activity and pancreatic lipase immunoreactivity in healthy cats

• Published in: Journal of veterinary internal medicine 2024-05, Vol.38 (3), p.1370-1376
• Main Authors: Pacheva, Militsa, Brugger, Daniel, Riond, Barbara, Dennler, Matthias, Kook, Peter Hendrik
• Format: Article
• Language: English
• Subjects: Animals; Biochemistry; cat; Cats; corticosteroids; Female; Glutarates; Lipase - blood; Lipase - metabolism; Male; Oxazines; Pancreas - drug effects; Pancreas - enzymology; pancreatic enzymes; Pancreatitis; Prednisolone - administration & dosage; Prednisolone - pharmacology; Prednisolone - therapeutic use; Prospective Studies; Regression analysis; SMALL ANIMAL; Steroids; triglyceride
• ISSN: 0891-6640; 1939-1676; 1939-1676
• DOI: 10.1111/jvim.17042

Background Corticosteroids are among the most commonly used drugs in cats and are increasingly discussed as a treatment for feline pancreatitis. However, its effects on serum lipase in healthy cats remain unknown. Objectives To evaluate the effects of prednisolone on serum lipase activity and pancreatic lipase immunoreactivity (PLI) in cats. Animals Seven clinically healthy colony cats, aged 4 to 7 years, with unremarkable CBC/biochemistry panel were studied. Methods Prospective study: Prednisolone (1.1‐1.5 mg/kg, median 1.28 mg/kg PO) was given daily for 7 consecutive days. Lipase activity (LIPC Roche; RI, 8‐26 U/L) and PLI (Spec fPL; RI, 0‐3.5 μg/L) were determined at day 1 before first treatment and at days 2, 3, 8, 10, and 14. Cats were examined daily. An a priori power analysis indicated that 6 cats were needed to find a biological relevant effect at 1‐β = 0.8. Statistical analyses comprised the Friedman test, random intercept regression, and repeated‐measures linear regression. Results Median (range) day 1 lipase activities and PLI were 22 U/L (14‐52 U/L) and 3.2 μg/L (2.3‐15.7 μg/L). One cat with abnormally high lipase activity (52 U/L) and PLI (15.7 μg/L) at day 1 continued having elevated lipase activities and PLI throughout the study. Lipase activities and PLI concentrations did not differ significantly among time points regardless of whether the cat with elevated values was included or not. All cats remained healthy throughout the study. Conclusions and Clinical Importance Administration of prednisolone in anti‐inflammatory doses does not significantly increase serum lipase activity and PLI concentration.