Omega-7 oil increases telomerase activity and accelerates healing of grafted burn and donor site wounds

This study investigated the efficacy of Omega-7 isolated from the sea buckthorn oil (Polyvit Co., Ltd, Gangar Holding, Ulaanbaatar, Mongolia) in ovine burn wound healing models. In vitro, proliferation (colony-forming rate) and migration (scratch) assays using cultured primary ovine keratinocytes we...

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Bibliographic Details
Published in:Scientific reports 2021-01, Vol.11 (1), p.975-975, Article 975
Main Authors: Niimi, Yosuke, Pérez-Bello, Dannelys, Ihara, Koji, Fukuda, Satoshi, Jacob, Sam, Andersen, Clark R., Baljinnyam, Tuvshintugs, Kim, Jisoo, Alharbi, Suzan, Prough, Donald S., Enkhbaatar, Perenlei
Format: Article
Language:English
Subjects:
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631/337
631/449
692/699
Blood flow
Colonies
Growth factors
Humanities and Social Sciences
Keratinocyte growth factor
Keratinocytes
multidisciplinary
Nitrotyrosine
Oil
Science
Science (multidisciplinary)
Telomerase
Topical application
Wound healing
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Summary:This study investigated the efficacy of Omega-7 isolated from the sea buckthorn oil (Polyvit Co., Ltd, Gangar Holding, Ulaanbaatar, Mongolia) in ovine burn wound healing models. In vitro, proliferation (colony-forming rate) and migration (scratch) assays using cultured primary ovine keratinocytes were performed with or without 0.025% and 0.08% Omega-7, respectively. The colony-forming rate of keratinocytes in the Omega-7 group at 72 and 96 h were significantly higher than in the control (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-79597-0