A Novel Enzootic Nasal Tumor Virus Circulating in Goats from Southern China

Enzootic nasal tumor virus (ENTV) has two types, ENTV-1 in sheep and ENTV-2 in goats, respectively. In China, the incidence of ENTV-2 related diseases has increased year by year. In this study, we reported an outbreak of ENTV-2 in a commercial goat farm in Qingyuan city, Guangdong province, southern...

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Bibliographic Details
Published in:Viruses 2019-10, Vol.11 (10), p.956
Main Authors: Zhai, Shao-Lun, Lv, Dian-Hong, Xu, Zhi-Hong, Yu, Jie-Shi, Wen, Xiao-Hui, Zhang, He, Chen, Qin-Ling, Jia, Chun-Ling, Zhou, Xiu-Rong, Zhai, Qi, Li, Feng, Woo, Patrick C. Y., Lau, Susanna K. P., Wang, Dan, Wei, Wen-Kang
Format: Article
Language:English
Subjects:
Amino acids
Animal diseases
Cloning
Communication
Dyspnea
entv-2
Env gene
enzootic nasal tumor virus
Epidemiology
Gag protein
Gene deletion
Genes
Genetic diversity
Genomes
goats
guangdong province
Head & neck cancer
Insertion
Maximum likelihood method
novel variation
Nucleotide sequence
Pathogenicity
Phylogenetics
Phylogeny
Proteins
Tumor viruses
Viruses
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Summary:Enzootic nasal tumor virus (ENTV) has two types, ENTV-1 in sheep and ENTV-2 in goats, respectively. In China, the incidence of ENTV-2 related diseases has increased year by year. In this study, we reported an outbreak of ENTV-2 in a commercial goat farm in Qingyuan city, Guangdong province, southern China. A full-length genome of ENTV-2 (designated GDQY2017), with 7479 base pairs, was sequenced. Although GDQY2017 shared the highest nucleotide identity with a Chinese ENTV-2 isolate (ENTV-2CHN4, GenBank accession number KU258873), it possesses distinct genome characteristics undescribed, including a non-continuous 21-nucleotide insertion in the gag gene and a non-continuous 12-nucleotide deletion in the env gene. Notably, most of these indel nucleotide sequences were originated from a Chinese jaagsiekte sheep retrovirus (JSRV) isolate (GenBank accession number DQ838494). In the gag and env genes, GDQY2017 was phylogenetically related to those Chinese ENTV-2 isolates and a Chinese JSRV isolate (DQ838494). For GDQY2017-like viruses, more surveillance work should be made to explain their pathogenicity in goat herds. To our knowledge, this study represents the first to demonstrate the circulating pattern of ENTV-2 in Guangdong province, China, which will help to better understand the epidemiology and genetic diversity of ENTV-2.
ISSN:1999-4915
1999-4915
DOI:10.3390/v11100956