The effects of antiretroviral therapy initiation time on HIV reservoir size in Chinese chronically HIV infected patients: a prospective, multi-site cohort study

The effect of ART initiation time on HIV-1 DNA reservoir in chronically infected individuals is not well understood. Determining the potential influencing factors associated with a low HIV-1 DNA level in chronic infection is an important step toward drug-free control. A prospective study included 44...

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Bibliographic Details
Published in:BMC infectious diseases 2019-03, Vol.19 (1), p.257-257, Article 257
Main Authors: Luo, Ling, Wang, Nidan, Yue, Yongsong, Han, Yang, Lv, Wei, Liu, Zhengyin, Qiu, Zhifeng, Lu, Hongzhou, Tang, Xiaoping, Zhang, Tong, Zhao, Min, He, Yun, Shenghua, He, Wang, Min, Li, Yongzhen, Huang, Shaobiao, Li, Yong, Liu, Jing, Tuofu, Zhu, Routy, Jean-Pierre, Li, Taisheng
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adolescent
Adult
Adults
Aged
AIDS
Analysis
Anti-HIV Agents - therapeutic use
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Care and treatment
CD4 antigen
CD4 Lymphocyte Count
CD4-CD8 Ratio
CD8 antigen
Chronic infection
Clinical trials
Cohort analysis
Cohort Studies
Control methods
Deoxyribonucleic acid
DNA
DNA reservoir
DNA, Viral
Drug therapy
Female
Genetic research
Highly active antiretroviral therapy
HIV
HIV Infections - drug therapy
HIV Infections - virology
HIV patients
HIV tests
HIV-1
HIV-1 - genetics
Human immunodeficiency virus
Humans
Infection
Infections
Infectious diseases
Initiation time
Leukocytes, Mononuclear
Levels
Lymphocytes
Male
Mann-Whitney U test
Middle Aged
Polymerase chain reaction
Prospective Studies
Real-Time Polymerase Chain Reaction
Time-to-Treatment
Viral Load
Young Adult
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Summary:The effect of ART initiation time on HIV-1 DNA reservoir in chronically infected individuals is not well understood. Determining the potential influencing factors associated with a low HIV-1 DNA level in chronic infection is an important step toward drug-free control. A prospective study included 444 chronically HIV-infected adults was performed. Participants were divided into two groups: early initiation group (EIG) or delayed initiation group (DIG) based on their baseline CD4 count; 350 to 500 and 
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-019-3847-0