Different Immune Responses in Dangerous O Blood Donors

Dangerous O is very important to transfusion medicine and there has been reports by Food and Drug Administration (FDA) regarding some death relating incidences. As high iso-antibody production is closely associated with different immune reactions, a survey on the different immune response of dangero...

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Bibliographic Details
Published in:Iranian journal of pathology 2020, Vol.15 (1), p.34-40
Main Authors: Arabi, Shaghayegh, Moghaddam, Mostafa, Maleki, Vida, Pourfathollah, Ali Akbar, Aghaie, Afsaneh
Format: Article
Language:English
Subjects:
dangerous o
high responder donors
immune response
iso-antibody
Short Communication
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Summary:Dangerous O is very important to transfusion medicine and there has been reports by Food and Drug Administration (FDA) regarding some death relating incidences. As high iso-antibody production is closely associated with different immune reactions, a survey on the different immune response of dangerous O donors can lead to understanding their immune response profile. Objectives were to assess different immune responses in dangerous O cases. Two groups of donors were selected after performing titration as a high titer (>512) and non-high titer (
ISSN:1735-5303
2345-3656
DOI:10.30699/ijp.2019.104673.2075