Comparison of overall survival and perioperative outcomes of laparoscopic pancreaticoduodenectomy and open pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: a systematic review and meta-analysis

The aim of this study was to compare the oncological outcomes and clinical efficacy of laparoscopic pancreaticoduodenectomy (LPD) and open pancreaticoduodenectomy (OPD) in patients with pancreatic ductal adenocarcinoma (PDAC). We systematically searched PubMed, EMBASE, Web of Science, ClinicalTrials...

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Bibliographic Details
Published in:BMC cancer 2019-08, Vol.19 (1), p.781-781, Article 781
Main Authors: Jiang, Yu-Li, Zhang, Ren-Chao, Zhou, Yu-Cheng
Format: Article
Language:English
Subjects:
Adenocarcinoma
Cancer research
Carcinoma, Pancreatic Ductal - diagnosis
Carcinoma, Pancreatic Ductal - mortality
Carcinoma, Pancreatic Ductal - surgery
Care and treatment
Female
Fistulas
Hemorrhage
Humans
Laparoscopic pancreaticoduodenectomy
Laparoscopy
Laparoscopy - adverse effects
Laparoscopy - methods
Male
Medical research
Neoplasm Grading
Neoplasm Staging
Oncological outcome
Open pancreaticoduodenectomy
Operating systems (Software)
Pancreatic cancer
Pancreatic Neoplasms
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - surgery
Pancreaticoduodenectomy
Pancreaticoduodenectomy - adverse effects
Pancreaticoduodenectomy - methods
Patient outcomes
PDAC
Perioperative Care
Postoperative Complications - etiology
Prognosis
Surgery
Treatment Outcome
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Summary:The aim of this study was to compare the oncological outcomes and clinical efficacy of laparoscopic pancreaticoduodenectomy (LPD) and open pancreaticoduodenectomy (OPD) in patients with pancreatic ductal adenocarcinoma (PDAC). We systematically searched PubMed, EMBASE, Web of Science, ClinicalTrials.gov and the Cochrane Central Register for studies published between May 1998 and May 2018. The included studies compared LPD and OPD for the treatment of PDAC. The oncological outcomes and perioperative data were analyzed. Eight studies involving 15,278 patients were included in our meta-analysis. No significant difference was found in the 5-year overall survival (OS) between patients undergoing the two types of surgery (HR: 0.97, 95% CI 0.82-1.15, p = 0.76). LPD resulted in a higher rate of R0 resection than OPD (OR: 1.16, 95% CI 0.85-1.57, p > 0.05). This study showed that compared with OPD, LPD resulted in comparable rates of postoperative pancreatic fistulas (POPFs) (OR: 1.07, 95% CI: 0.68-1.68, p = 0.77) and postoperative hemorrhage (OR: 1.74, 95% CI 0.96-3.71, p = 0.07), more harvested lymph nodes (WMD: 1.84, 95% CI: 0.95-2.72, p 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-019-6001-x