Plasma circRNAs as Biomarkers in Cancer

The incidence and mortality of cancer are increasing each year. At present, the sensitivity and specificity of the blood biomarkers that were used in clinical practice are low, which make the detection rate of cancer decrease. With advances in bioinformatics and technology, some non-coding RNA as bi...

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Bibliographic Details
Published in:Cancer management and research 2021-01, Vol.13, p.7325-7337
Main Authors: Zhou, Qian, Ju, Lin-Ling, Ji, Xiang, Cao, Ya-Li, Shao, Jian-Guo, Chen, Lin
Format: Article
Language:English
Subjects:
Antigens
Binding sites
Biological markers
Biomarkers
Biopsy
Biosynthesis
Cancer
Cell cycle
China
circular rna
Cyclin-dependent kinases
Development and progression
Gene expression
Growth factors
Health aspects
Kinases
Lung cancer
Mortality
Plasma
Proteins
Review
RNA
RNA polymerase
Tumors
Womens health
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Summary:The incidence and mortality of cancer are increasing each year. At present, the sensitivity and specificity of the blood biomarkers that were used in clinical practice are low, which make the detection rate of cancer decrease. With advances in bioinformatics and technology, some non-coding RNA as biomarkers can be easily detected through some traditional and new technologies. Circular RNAs (circRNAs) are non-coding RNAs, that is, they do not encode proteins, and have important regulatory functions. CircRNAs can remain stable in bodily fluids, such as in saliva, blood, urine, and especially plasma. The difference in the expression of plasma circRNAs between cancer patients and normal people may suggest that plasma circRNAs may play an important role in the occurrence and development of cancer. In this review, we summarized the clinical effect of plasma circRNAs in several high-incidence cancers. CircRNAs may be effective biomarkers for tumour diagnosis, treatment selection and prognosis evaluation.
ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S330228