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Comparative clinicopathological and outcome analysis of differentiated thyroid cancer in Saudi patients aged below 60 years and above 60 years
The aim of this study was to evaluate the treatment outcomes of differentiated thyroid cancer in Saudi patients aged above 60 years. Comparative analysis was performed in 252 patients aged 46-60 years (Group A) and 118 patients aged above 60 years (Group B), who had thyroidectomy, radioactive iodine...
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| Published in: | Clinical interventions in aging 2016-01, Vol.11, p.1169-1174 |
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| container_title | Clinical interventions in aging |
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| creator | Al-Qahtani, Khalid Hussain Tunio, Mutahir A Asiri, Mushabbab Al Bayoumi, Yasser Balbaid, Ali Aljohani, Naji J Fatani, Hanadi |
| description | The aim of this study was to evaluate the treatment outcomes of differentiated thyroid cancer in Saudi patients aged above 60 years.
Comparative analysis was performed in 252 patients aged 46-60 years (Group A) and 118 patients aged above 60 years (Group B), who had thyroidectomy, radioactive iodine-131, and thyroid-stimulating hormone suppression therapy between July 2000 and December 2012. Different clinicopathological features, treatment, complications, disease-free survival, and overall survival rates were compared.
Mean age of patients in Group A was 51.9 years (range: 46-60), and mean age of those in Group B was 68.6 years (range: 62-97). Group B patients had higher positive lymph nodes (43.2%), P=0.011. The frequency of extrathyroidal extension, multifocality, and lymphovascular space invasion was seen more in Group B than in Group A. Postsurgical complications (permanent hypoparathyroidism, bleeding, and wound infections) were also seen more in Group B (P=0.043, P=0.011, and P=0.021, respectively). Group B patients experienced more locoregional recurrences (11.0%, P=0.025); similarly, more distant metastases were observed in Group B (15.3%, P=0.003). The 10-year disease-free survival rates were 87.6% in Group A and 70.8% in Group B (P |
| doi_str_mv | 10.2147/CIA.S107881 |
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Comparative analysis was performed in 252 patients aged 46-60 years (Group A) and 118 patients aged above 60 years (Group B), who had thyroidectomy, radioactive iodine-131, and thyroid-stimulating hormone suppression therapy between July 2000 and December 2012. Different clinicopathological features, treatment, complications, disease-free survival, and overall survival rates were compared.
Mean age of patients in Group A was 51.9 years (range: 46-60), and mean age of those in Group B was 68.6 years (range: 62-97). Group B patients had higher positive lymph nodes (43.2%), P=0.011. The frequency of extrathyroidal extension, multifocality, and lymphovascular space invasion was seen more in Group B than in Group A. Postsurgical complications (permanent hypoparathyroidism, bleeding, and wound infections) were also seen more in Group B (P=0.043, P=0.011, and P=0.021, respectively). Group B patients experienced more locoregional recurrences (11.0%, P=0.025); similarly, more distant metastases were observed in Group B (15.3%, P=0.003). The 10-year disease-free survival rates were 87.6% in Group A and 70.8% in Group B (P<0.0001).
Differentiated thyroid cancer in patients aged above 60 years are more aggressive biologically and associated with a worse prognosis, and the morbidity is significantly high as compared to patients aged below 60 years.</description><identifier>ISSN: 1178-1998</identifier><identifier>ISSN: 1176-9092</identifier><identifier>EISSN: 1178-1998</identifier><identifier>DOI: 10.2147/CIA.S107881</identifier><identifier>PMID: 27621604</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>Age ; age below 60 years ; Age Factors ; Aged ; aged above 60 years ; Aged, 80 and over ; Cancer therapies ; Care and treatment ; clinicopathological characteristics ; Differentiated thyroid cancers ; Disease ; Disease-Free Survival ; elderly patients. comparative analysis ; Female ; Food Contamination, Radioactive ; Geriatrics ; Humans ; Hypocalcemia ; Iodine ; Iodine Radioisotopes - therapeutic use ; Kaplan-Meier Estimate ; Lymphatic system ; Male ; Medical imaging ; Metastasis ; Middle Aged ; Neck ; Older people ; Oncology ; Original Research ; Patients ; patients aged above 45 years ; Postoperative Complications - epidemiology ; Postoperative Hemorrhage ; Retrospective Studies ; Saudi Arabia ; Surgery ; Thyroid cancer ; Thyroid Neoplasms - classification ; Thyroid Neoplasms - therapy ; Thyroidectomy ; Thyrotropin ; Thyrotropin - antagonists & inhibitors ; Treatment Outcome ; treatment outcomes</subject><ispartof>Clinical interventions in aging, 2016-01, Vol.11, p.1169-1174</ispartof><rights>COPYRIGHT 2016 Dove Medical Press Limited</rights><rights>2016. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 AL-Qahtani et al. This work is published and licensed by Dove Medical Press Limited 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-8fd2d694adf9060f5f7a85c6d85b7e357cd520ff3c6c107cb92fb5eeb7b893533</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2224701140/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2224701140?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27621604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al-Qahtani, Khalid Hussain</creatorcontrib><creatorcontrib>Tunio, Mutahir A</creatorcontrib><creatorcontrib>Asiri, Mushabbab Al</creatorcontrib><creatorcontrib>Bayoumi, Yasser</creatorcontrib><creatorcontrib>Balbaid, Ali</creatorcontrib><creatorcontrib>Aljohani, Naji J</creatorcontrib><creatorcontrib>Fatani, Hanadi</creatorcontrib><title>Comparative clinicopathological and outcome analysis of differentiated thyroid cancer in Saudi patients aged below 60 years and above 60 years</title><title>Clinical interventions in aging</title><addtitle>Clin Interv Aging</addtitle><description>The aim of this study was to evaluate the treatment outcomes of differentiated thyroid cancer in Saudi patients aged above 60 years.
Comparative analysis was performed in 252 patients aged 46-60 years (Group A) and 118 patients aged above 60 years (Group B), who had thyroidectomy, radioactive iodine-131, and thyroid-stimulating hormone suppression therapy between July 2000 and December 2012. Different clinicopathological features, treatment, complications, disease-free survival, and overall survival rates were compared.
Mean age of patients in Group A was 51.9 years (range: 46-60), and mean age of those in Group B was 68.6 years (range: 62-97). Group B patients had higher positive lymph nodes (43.2%), P=0.011. The frequency of extrathyroidal extension, multifocality, and lymphovascular space invasion was seen more in Group B than in Group A. Postsurgical complications (permanent hypoparathyroidism, bleeding, and wound infections) were also seen more in Group B (P=0.043, P=0.011, and P=0.021, respectively). Group B patients experienced more locoregional recurrences (11.0%, P=0.025); similarly, more distant metastases were observed in Group B (15.3%, P=0.003). The 10-year disease-free survival rates were 87.6% in Group A and 70.8% in Group B (P<0.0001).
Differentiated thyroid cancer in patients aged above 60 years are more aggressive biologically and associated with a worse prognosis, and the morbidity is significantly high as compared to patients aged below 60 years.</description><subject>Age</subject><subject>age below 60 years</subject><subject>Age Factors</subject><subject>Aged</subject><subject>aged above 60 years</subject><subject>Aged, 80 and over</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>clinicopathological characteristics</subject><subject>Differentiated thyroid cancers</subject><subject>Disease</subject><subject>Disease-Free Survival</subject><subject>elderly patients. comparative analysis</subject><subject>Female</subject><subject>Food Contamination, Radioactive</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Hypocalcemia</subject><subject>Iodine</subject><subject>Iodine Radioisotopes - therapeutic use</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neck</subject><subject>Older people</subject><subject>Oncology</subject><subject>Original Research</subject><subject>Patients</subject><subject>patients aged above 45 years</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Hemorrhage</subject><subject>Retrospective Studies</subject><subject>Saudi Arabia</subject><subject>Surgery</subject><subject>Thyroid cancer</subject><subject>Thyroid Neoplasms - classification</subject><subject>Thyroid Neoplasms - therapy</subject><subject>Thyroidectomy</subject><subject>Thyrotropin</subject><subject>Thyrotropin - antagonists & inhibitors</subject><subject>Treatment Outcome</subject><subject>treatment outcomes</subject><issn>1178-1998</issn><issn>1176-9092</issn><issn>1178-1998</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkl2LEzEUhgdR3HX1ynsJCCJIa5KZTDI3C0vxo7Dgxep1OJOPNiUzqUlmpX_C32x2211bkVwknDx5Qk7eqnpN8JyShn9cLK_mNwRzIciT6pwQLmak68TTo_VZ9SKlDcas5Yw-r84obylpcXNe_V6EYQsRsrs1SHk3OhW2kNfBh5VT4BGMGoUpqzCYsga_Sy6hYJF21ppoxuwgG43yeheD00jBqExEbkQ3MGmHissVKCFYFao3PvxCLUY7AzHdu6EP5eaH0svqmQWfzKvDfFH9-Pzp--Lr7Prbl-Xi6nqmGK_zTFhNdds1oG2HW2yZ5SCYarVgPTc140oziq2tVatKZ1TfUdszY3rei65mdX1RLfdeHWAjt9ENEHcygJP3hRBXEmJ2yhtpbWuBCrANF02taY-twX3DlOh4T4gtrsu9azv1g9GqPDeCP5Ge7oxuLVfhVjJMMOZtEbw_CGL4OZmU5eCSMt7DaMKUJBGka2oqal7Qt_-gmzDF8i1JUkobjglp8F9qBeUBbrSh3KvupPKK4Zp2bWlKoeb_ocrQZigpGI11pX5y4N3RgbUBn9cp-Cm7MKZT8MMeVDGkFI19bAbB8i6zsmRWHjJb6DfH_XtkH0Ja_wE40-cy</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Al-Qahtani, Khalid Hussain</creator><creator>Tunio, Mutahir A</creator><creator>Asiri, Mushabbab Al</creator><creator>Bayoumi, Yasser</creator><creator>Balbaid, Ali</creator><creator>Aljohani, Naji J</creator><creator>Fatani, Hanadi</creator><general>Dove Medical Press Limited</general><general>Taylor & Francis Ltd</general><general>Dove Medical Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7XB</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>KB0</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20160101</creationdate><title>Comparative clinicopathological and outcome analysis of differentiated thyroid cancer in Saudi patients aged below 60 years and above 60 years</title><author>Al-Qahtani, Khalid Hussain ; Tunio, Mutahir A ; Asiri, Mushabbab Al ; Bayoumi, Yasser ; Balbaid, Ali ; Aljohani, Naji J ; Fatani, Hanadi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-8fd2d694adf9060f5f7a85c6d85b7e357cd520ff3c6c107cb92fb5eeb7b893533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Age</topic><topic>age below 60 years</topic><topic>Age Factors</topic><topic>Aged</topic><topic>aged above 60 years</topic><topic>Aged, 80 and over</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>clinicopathological characteristics</topic><topic>Differentiated thyroid cancers</topic><topic>Disease</topic><topic>Disease-Free Survival</topic><topic>elderly patients. comparative analysis</topic><topic>Female</topic><topic>Food Contamination, Radioactive</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Hypocalcemia</topic><topic>Iodine</topic><topic>Iodine Radioisotopes - therapeutic use</topic><topic>Kaplan-Meier Estimate</topic><topic>Lymphatic system</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neck</topic><topic>Older people</topic><topic>Oncology</topic><topic>Original Research</topic><topic>Patients</topic><topic>patients aged above 45 years</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Hemorrhage</topic><topic>Retrospective Studies</topic><topic>Saudi Arabia</topic><topic>Surgery</topic><topic>Thyroid cancer</topic><topic>Thyroid Neoplasms - classification</topic><topic>Thyroid Neoplasms - therapy</topic><topic>Thyroidectomy</topic><topic>Thyrotropin</topic><topic>Thyrotropin - antagonists & inhibitors</topic><topic>Treatment Outcome</topic><topic>treatment outcomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Qahtani, Khalid Hussain</creatorcontrib><creatorcontrib>Tunio, Mutahir A</creatorcontrib><creatorcontrib>Asiri, Mushabbab Al</creatorcontrib><creatorcontrib>Bayoumi, Yasser</creatorcontrib><creatorcontrib>Balbaid, Ali</creatorcontrib><creatorcontrib>Aljohani, Naji J</creatorcontrib><creatorcontrib>Fatani, Hanadi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Clinical interventions in aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Qahtani, Khalid Hussain</au><au>Tunio, Mutahir A</au><au>Asiri, Mushabbab Al</au><au>Bayoumi, Yasser</au><au>Balbaid, Ali</au><au>Aljohani, Naji J</au><au>Fatani, Hanadi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative clinicopathological and outcome analysis of differentiated thyroid cancer in Saudi patients aged below 60 years and above 60 years</atitle><jtitle>Clinical interventions in aging</jtitle><addtitle>Clin Interv Aging</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>11</volume><spage>1169</spage><epage>1174</epage><pages>1169-1174</pages><issn>1178-1998</issn><issn>1176-9092</issn><eissn>1178-1998</eissn><abstract>The aim of this study was to evaluate the treatment outcomes of differentiated thyroid cancer in Saudi patients aged above 60 years.
Comparative analysis was performed in 252 patients aged 46-60 years (Group A) and 118 patients aged above 60 years (Group B), who had thyroidectomy, radioactive iodine-131, and thyroid-stimulating hormone suppression therapy between July 2000 and December 2012. Different clinicopathological features, treatment, complications, disease-free survival, and overall survival rates were compared.
Mean age of patients in Group A was 51.9 years (range: 46-60), and mean age of those in Group B was 68.6 years (range: 62-97). Group B patients had higher positive lymph nodes (43.2%), P=0.011. The frequency of extrathyroidal extension, multifocality, and lymphovascular space invasion was seen more in Group B than in Group A. Postsurgical complications (permanent hypoparathyroidism, bleeding, and wound infections) were also seen more in Group B (P=0.043, P=0.011, and P=0.021, respectively). Group B patients experienced more locoregional recurrences (11.0%, P=0.025); similarly, more distant metastases were observed in Group B (15.3%, P=0.003). The 10-year disease-free survival rates were 87.6% in Group A and 70.8% in Group B (P<0.0001).
Differentiated thyroid cancer in patients aged above 60 years are more aggressive biologically and associated with a worse prognosis, and the morbidity is significantly high as compared to patients aged below 60 years.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>27621604</pmid><doi>10.2147/CIA.S107881</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1178-1998 |
| ispartof | Clinical interventions in aging, 2016-01, Vol.11, p.1169-1174 |
| issn | 1178-1998 1176-9092 1178-1998 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_ff6fa28af47843d2b0fe0b45c897b11f |
| source | Taylor & Francis Open Access; Publicly Available Content (ProQuest); PubMed Central |
| subjects | Age age below 60 years Age Factors Aged aged above 60 years Aged, 80 and over Cancer therapies Care and treatment clinicopathological characteristics Differentiated thyroid cancers Disease Disease-Free Survival elderly patients. comparative analysis Female Food Contamination, Radioactive Geriatrics Humans Hypocalcemia Iodine Iodine Radioisotopes - therapeutic use Kaplan-Meier Estimate Lymphatic system Male Medical imaging Metastasis Middle Aged Neck Older people Oncology Original Research Patients patients aged above 45 years Postoperative Complications - epidemiology Postoperative Hemorrhage Retrospective Studies Saudi Arabia Surgery Thyroid cancer Thyroid Neoplasms - classification Thyroid Neoplasms - therapy Thyroidectomy Thyrotropin Thyrotropin - antagonists & inhibitors Treatment Outcome treatment outcomes |
| title | Comparative clinicopathological and outcome analysis of differentiated thyroid cancer in Saudi patients aged below 60 years and above 60 years |
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