Decreased ventricular systolic function in chemotherapy-naive patients with acute myeloid leukemia: a three-dimensional speckle-tracking echocardiography study

• Published in: Frontiers in cardiovascular medicine 2023-06, Vol.10, p.1140234-1140234
• Main Authors: Zhang, Yichan, Tan, Yuting, Liu, Tianshu, Fu, Yanan, Lin, Yixia, Shi, Jiawei, Zhang, Yanting, Deng, Wenhui, He, Shukun, Yang, Yali, Lv, Qing, Zhang, Li, Xie, Mingxing, Wang, Jing
• Format: Article
• Language: English
• Subjects: acute myeloid leukemia; Cardiovascular Medicine; oncology cardiology, echocardiography; three-dimensional speckle-tracking strain; ventricular systolic function
• ISSN: 2297-055X; 2297-055X
• DOI: 10.3389/fcvm.2023.1140234

The relationship between acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) and cardiac function is not well established. This study aimed to evaluate whether AML patients exist early myocardial damages prior to chemotherapy and to investigate its association with cardiovascular biomarkers. Conventional echocardiography and three-dimensional speckle-tracking strain analysis were performed prospectively in 72 acute leukemia (AL) patients before any chemotherapy therapy (of whom 44 were AML patients, 28 ALL patients). The results were compared with those from 58 control group matched for age and gender. There were no significant differences in conventional biventricular systolic function parameters between AL patients and controls. The left ventricular global longitudinal strain (LVGLS) and right ventricular free wall longitudinal strain (RVFWLS) were significantly lower in AL patients (-23.0 ± 1.4% vs. -24.1 ± 1.3% and -27.9 ± 7.1% vs. -33.0 ± 4.6%, respectively,