In vitro characterization of virulence factors among species of the Candida parapsilosis complex

Candida parapsilosis complex species differ from each other with regard to their prevalence and virulence. The hydrolytic enzyme activity, biofilm production, and adhesion to epithelial cells were analyzed in 87 C. parapsilosis complex strains. Among the studied isolates, 97.7%, 63.2%, and 82.8% exh...

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Published in:Revista da Sociedade Brasileira de Medicina Tropical 2020-01, Vol.53, p.e20190336-e20190336
Main Authors: Ataides, Fábio Silvestre, Costa, Carolina Rodrigues, Santos, Andressa Santana, Freitas, Vivianny Aparecida Queiroz, Silva, Thaisa Cristina, Zara, Ana Laura Sene Amâncio, Jesuino, Rosália Santos Amorim, Silva, Maria Rosário Rodrigues
Format: Article
Language:English
Subjects:
Biofilms
Biofilms - growth & development
Candida parapsilosis
Candida parapsilosis - classification
Candida parapsilosis - enzymology
Candida parapsilosis - isolation & purification
Candida parapsilosis - pathogenicity
Cell Adhesion
Humans
Hydrolases - biosynthesis
Hydrolytic enzymes
Mycological Typing Techniques
Short Communication
TROPICAL MEDICINE
Virulence factors
Virulence Factors - analysis
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Summary:Candida parapsilosis complex species differ from each other with regard to their prevalence and virulence. The hydrolytic enzyme activity, biofilm production, and adhesion to epithelial cells were analyzed in 87 C. parapsilosis complex strains. Among the studied isolates, 97.7%, 63.2%, and 82.8% exhibited very strong proteinase, esterase, and hemolysin activity, respectively. All the C. parapsilosis complex isolates produced biofilms and presented an average adherence of 96.0 yeasts/100 epithelial cells. Our results show that Candida parapsilosis complex isolates showed different levels of enzyme activity, biofilm production, and adhesion to epithelial cells.
ISSN:0037-8682
1678-9849
1678-9849
DOI:10.1590/0037-8682-0336-2019