Benign Metastasizing Leiomyoma of the Uterus: Rare Manifestation of a Frequent Pathology

Benign Metastasizing Leiomyoma (BML) is a rare condition with few cases reported in the literature. It is usually incidentally diagnosed several years after a primary gynecological surgery for uterine leiomyoma. Differential diagnosis of BML is complex requiring an extensive work-up and exclusion of...

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Bibliographic Details
Published in:Case reports in obstetrics and gynecology 2018, Vol.2018 (2018), p.1-8
Main Authors: Petiz, Almerinda, Pires, Mónica, Ramalho, Cristina, Ormonde, Mariana, Cardoso, Mariana, Meireles, Catarina, Raposo, Maria Inês, Afonso, M.
Format: Article
Language:English
Subjects:
Appendectomy
Case Report
Case reports
Fibroids
Gynecology
Hysterectomy
Leiomyoma
Lungs
Metastasis
Microscopy
Mutation
Pathology
Smooth muscle
Surgery
Tomography
Tumors
Womens health
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Summary:Benign Metastasizing Leiomyoma (BML) is a rare condition with few cases reported in the literature. It is usually incidentally diagnosed several years after a primary gynecological surgery for uterine leiomyoma. Differential diagnosis of BML is complex requiring an extensive work-up and exclusion of malignancy. Here, we report two cases of BML based on similarity of histopathological, immunohistochemical, and genetic patterns between lung nodules and uterine leiomyoma previously resected, evidencing the variability of clinical and radiological features of BML. We highlight the importance of 19q and 22q deletions as highly suggestive of BML. These findings are particularly relevant when there is no uterine sample for review.
ISSN:2090-6684
2090-6692
DOI:10.1155/2018/5067276