Correlation of age and sex with urine dehydroepiandrosterone sulfate level in healthy Thai volunteers

Dehydroepiandrosterone sulfate (DHEAs), a prohormone secreted by the adrenal gland, plays a role in the synthesis of sex hormones, namely, androgen and estrogen. It has been found that the amount of DHEAs is correlated with age, although most studies have focused on the correlation of serum DHEAs le...

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Bibliographic Details
Published in:Practical laboratory medicine 2021-03, Vol.24, p.e00204-e00204, Article e00204
Main Authors: Krorakai, Karnpimon, Tontipattananon, Siriporn, Leemahanil, Rattikorn, Klangphukhiew, Supannika, Wongrathanandha, Chathaya, Phaibulpanich, Akarin, Patramanon, Rina
Format: Article
Language:English
Subjects:
Age
Dehydroepiandrosterone sulfate
Sex
Urine
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Summary:Dehydroepiandrosterone sulfate (DHEAs), a prohormone secreted by the adrenal gland, plays a role in the synthesis of sex hormones, namely, androgen and estrogen. It has been found that the amount of DHEAs is correlated with age, although most studies have focused on the correlation of serum DHEAs levels with age and sex. Thus, this noninvasive, cross-sectional study aimed to investigate the correlation of urine DHEAs levels with age and sex in healthy Thai volunteers aged 20–80 years. DHEAs levels were measured in 178 healthy volunteers using electrochemiluminescence immunoassay and then normalized by creatinine. Multiple regression was performed to determine the correlation of urine DHEAs levels normalized by creatinine with age and sex. The normalized DHEAs levels are correlated with age group for both sexes. Moreover, an increasing trend in DHEAs levels was found in the age group 20–29 years, and the DHEAs level peaked at the age group 30–39 years before declining with advancing age. Based on the multiple regression analyses, the significance of the interaction term (P ​
ISSN:2352-5517
2352-5517
DOI:10.1016/j.plabm.2021.e00204