Anticonvulsant Effect of Diazoxide against Dichlorvos-Induced Seizures in Mice

Dichlorvos, a synthetic organophosphate toxin, is used as pesticides. These toxins can be used as pesticides in farming and medicine for the devastation and/or elimination of ectoparasites of animals. Reports have shown that Dichlorvos generate seizure effects in various animals. Potassium channel o...

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Bibliographic Details
Published in:TheScientificWorld 2013-01, Vol.2013 (2013), p.1-4
Main Authors: Jazayeri, Amin, Ostadhadi, Sattar, Zolfaghari, Samira
Format: Article
Language:English
Subjects:
Animal models
Animals
Anticonvulsants
Anticonvulsants - pharmacology
Antihypertensive Agents - pharmacology
Brain research
Convulsions & seizures
Diazoxide - pharmacology
Dichlorvos
Dichlorvos - adverse effects
Dichlorvos - pharmacology
Dose-Response Relationship, Drug
Ectoparasites
Epilepsy
Injection
Insecticides - adverse effects
Insecticides - pharmacology
Latency
Male
Mice
Organophosphates
Pesticides
Pharmacology
Potassium
Potassium channels
Potassium Channels - metabolism
Rodents
Seizures
Seizures - chemically induced
Seizures - drug therapy
Seizures - metabolism
Seizures - physiopathology
Toxins
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Summary:Dichlorvos, a synthetic organophosphate toxin, is used as pesticides. These toxins can be used as pesticides in farming and medicine for the devastation and/or elimination of ectoparasites of animals. Reports have shown that Dichlorvos generate seizure effects in various animals. Potassium channel opener is extensively used for medication of cardiovascular and other diseases. Studies have shown that potassium channel opener has anticonvulsant effects in different animal models. The goal of this study was to evaluate the effect of dizoxide on Dichlorvos-induced seizures in mice. In this research, the animals received different doses of Diazoxide (1, 2.5, 5, 10, and 20 mg/kg b.wt.) intraperitoneally 30 min before intraperitoneal injection of Dichlorvos (50 mg/kg b.w.t). After Dichlorvos injection, latency of clones, severity of seizure, and finally death as the fate were investigated. Results showed that Diazoxide dose-dependently decreased the severity of Dichlorvos-induced seizures, so that Diazoxide at a dose of 5 mg (the lowest, P
ISSN:2356-6140
1537-744X
DOI:10.1155/2013/697305