Epigenetics of Hepatic Insulin Resistance

Insulin resistance (IR) is largely recognized as a unifying feature that underlies metabolic dysfunction. Both lifestyle and genetic factors contribute to IR. Work from recent years has demonstrated that the epigenome may constitute an interface where different signals may converge to promote IR gen...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2021-05, Vol.12, p.681356-681356
Main Authors: Maude, Hannah, Sanchez-Cabanillas, Claudia, Cebola, Inês
Format: Article
Language:English
Subjects:
Animals
Diabetes Mellitus, Type 2 - metabolism
DNA Methylation
Endocrinology
Epigenesis, Genetic - physiology
epigenetics (DNA methylation, histone modifications)
Genetic Loci
Humans
insulin resistance
Insulin Resistance - physiology
liver
Liver - metabolism
NAFLD (non-alcoholic fatty liver disease)
Non-alcoholic Fatty Liver Disease - metabolism
type 2 diabetes
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Summary:Insulin resistance (IR) is largely recognized as a unifying feature that underlies metabolic dysfunction. Both lifestyle and genetic factors contribute to IR. Work from recent years has demonstrated that the epigenome may constitute an interface where different signals may converge to promote IR gene expression programs. Here, we review the current knowledge of the role of epigenetics in hepatic IR, focusing on the roles of DNA methylation and histone post-translational modifications. We discuss the broad epigenetic changes observed in the insulin resistant liver and its associated pathophysiological states and leverage on the wealth of 'omics' studies performed to discuss efforts in pinpointing specific loci that are disrupted by these changes. We envision that future studies, with increased genomic resolution and larger cohorts, will further the identification of biomarkers of early onset hepatic IR and assist the development of targeted interventions. Furthermore, there is growing evidence to suggest that persistent epigenetic marks may be acquired over prolonged exposure to disease or deleterious exposures, highlighting the need for preventative medicine and long-term lifestyle adjustments to avoid irreversible or long-term alterations in gene expression.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2021.681356