Lactate-Dependent Regulation of Immune Responses by Dendritic Cells and Macrophages

For decades, lactate has been considered an innocuous bystander metabolite of cellular metabolism. However, emerging studies show that lactate acts as a complex immunomodulatory molecule that controls innate and adaptive immune cells’ effector functions. Thus, recent advances point to lactate as an...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2021-07, Vol.12, p.691134-691134
Main Authors: Manoharan, Indumathi, Prasad, Puttur D., Thangaraju, Muthusamy, Manicassamy, Santhakumar
Format: Article
Language:English
Subjects:
antitumor immunity
dendritic cells
GPR81/GPR132
Immunology
lactate signaling
macrophages
regulatory and inflammatory responses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:For decades, lactate has been considered an innocuous bystander metabolite of cellular metabolism. However, emerging studies show that lactate acts as a complex immunomodulatory molecule that controls innate and adaptive immune cells’ effector functions. Thus, recent advances point to lactate as an essential and novel signaling molecule that shapes innate and adaptive immune responses in the intestine and systemic sites. Here, we review these recent advances in the context of the pleiotropic effects of lactate in regulating diverse functions of immune cells in the tissue microenvironment and under pathological conditions.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.691134