Zika Virus Circulation in Mali

The circulation of Zika virus (ZIKV) in Mali has not been clearly characterized. Therefore, we conducted a serologic survey of 793 asymptomatic volunteers >15 years of age (2016), and 637 blood donors (2013) to assess the seroprevalence of ZIKV infection in 2 ecoclimatic regions of Mali, tropical...

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Bibliographic Details
Published in:Emerging infectious diseases 2020-05, Vol.26 (5), p.945-952
Main Authors: Diarra, Issa, Nurtop, Elif, Sangaré, Abdoul Karim, Sagara, Issaka, Pastorino, Boris, Sacko, Souleymane, Zeguimé, Amatigué, Coulibaly, Drissa, Fofana, Bakary, Gallian, Pierre, Priet, Stephane, Drexler, Jan Felix, Failloux, Anna-Bella, Dabo, Abdoulaye, Thera, Mahamadou Ali, Djimdé, Abdoulaye, Kouriba, Bourèma, Cauchemez, Simon, de Lamballerie, Xavier, Hozé, Nathanaël, Doumbo, Ogobara K
Format: Article
Language:English
Subjects:
Age
arbovirus
Asymptomatic
Blood & organ donations
Blood donation
Blood Donors
Enzyme-linked immunosorbent assay
Epidemics
Female
Fever
Genotype & phenotype
Guillain-Barre syndrome
Health aspects
Health care
Humans
Infection
Infections
Investigations
Life Sciences
Male
Mali
Mali - epidemiology
Medical research
Microbiology and Parasitology
Mosquitoes
Sample size
Seroepidemiologic Studies
seroprevalence
Sociodemographics
Surveys
Tropical diseases
vector-borne infections
Viral infections
Virology
viruses
Volunteers
Women
Zika Virus
Zika Virus Circulation in Mali
Zika Virus Infection - epidemiology
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Summary:The circulation of Zika virus (ZIKV) in Mali has not been clearly characterized. Therefore, we conducted a serologic survey of 793 asymptomatic volunteers >15 years of age (2016), and 637 blood donors (2013) to assess the seroprevalence of ZIKV infection in 2 ecoclimatic regions of Mali, tropical savannah and warm semiarid region, using ELISA and seroneutralization assays. The overall seroprevalence was ≈12% and increased with age, with no statistical difference between male and female participants. In the warm semiarid study sites we detected immunological markers of an outbreak that occurred in the late 1990s in 18% (95% CI 13%-23%) of participants. In tropical savannah sites, we estimated a low rate of endemic transmission, with 2.5% (95% CI 2.0%-3.1%) of population infected by ZIKV annually. These data demonstrate the circulation of ZIKV in Mali and provide evidence of a previously unidentified outbreak that occurred in the late 1990s.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2605.191383