The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease

It is well-recognized that the gut microbiota (GM) is crucial for gut function, metabolism, and energy cycles. The GM also has effects on neurological outcomes via many mechanisms, such as metabolite production and the gut-brain axis. Emerging evidence has gradually indicated that GM dysbiosis plays...

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Bibliographic Details
Published in:Frontiers in neurology 2019-11, Vol.10, p.1155-1155
Main Authors: Yang, Dongming, Zhao, Deming, Ali Shah, Syed Zahid, Wu, Wei, Lai, Mengyu, Zhang, Xixi, Li, Jie, Guan, Zhiling, Zhao, Huafen, Li, Wen, Gao, Hongli, Zhou, Xiangmei, Yang, Lifeng
Format: Article
Language:English
Subjects:
enteric nervous system
fecal transplant
gut microbiota
gut-brain axis
microbiota-targeted therapies
Neurology
parkinson's disease
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Summary:It is well-recognized that the gut microbiota (GM) is crucial for gut function, metabolism, and energy cycles. The GM also has effects on neurological outcomes via many mechanisms, such as metabolite production and the gut-brain axis. Emerging evidence has gradually indicated that GM dysbiosis plays a role in several neurological diseases, such as Parkinson's disease (PD), Alzheimer's disease, depression, and multiple sclerosis. Several studies have observed that PD patients generally suffer from gastrointestinal disorders and GM dysbiosis prior to displaying motor symptoms, but the specific link between the GM and PD is not clearly understood. In this review, we aim to summarize what is known regarding the correlation between the GM and PD pathologies, including direct, and indirect evidence.
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2019.01155