The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease

It is well-recognized that the gut microbiota (GM) is crucial for gut function, metabolism, and energy cycles. The GM also has effects on neurological outcomes via many mechanisms, such as metabolite production and the gut-brain axis. Emerging evidence has gradually indicated that GM dysbiosis plays...

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Published in:Frontiers in neurology 2019-11, Vol.10, p.1155-1155
Main Authors: Yang, Dongming, Zhao, Deming, Ali Shah, Syed Zahid, Wu, Wei, Lai, Mengyu, Zhang, Xixi, Li, Jie, Guan, Zhiling, Zhao, Huafen, Li, Wen, Gao, Hongli, Zhou, Xiangmei, Yang, Lifeng
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Language:English
Subjects:
enteric nervous system
fecal transplant
gut microbiota
gut-brain axis
microbiota-targeted therapies
Neurology
parkinson's disease
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cited_by cdi_FETCH-LOGICAL-c528t-590e596ebbbe61782d433d0ba083c27219772c80da9242240517691bed839d513
cites cdi_FETCH-LOGICAL-c528t-590e596ebbbe61782d433d0ba083c27219772c80da9242240517691bed839d513
container_end_page 1155
container_issue
container_start_page 1155
container_title Frontiers in neurology
container_volume 10
creator Yang, Dongming
Zhao, Deming
Ali Shah, Syed Zahid
Wu, Wei
Lai, Mengyu
Zhang, Xixi
Li, Jie
Guan, Zhiling
Zhao, Huafen
Li, Wen
Gao, Hongli
Zhou, Xiangmei
Yang, Lifeng
description It is well-recognized that the gut microbiota (GM) is crucial for gut function, metabolism, and energy cycles. The GM also has effects on neurological outcomes via many mechanisms, such as metabolite production and the gut-brain axis. Emerging evidence has gradually indicated that GM dysbiosis plays a role in several neurological diseases, such as Parkinson's disease (PD), Alzheimer's disease, depression, and multiple sclerosis. Several studies have observed that PD patients generally suffer from gastrointestinal disorders and GM dysbiosis prior to displaying motor symptoms, but the specific link between the GM and PD is not clearly understood. In this review, we aim to summarize what is known regarding the correlation between the GM and PD pathologies, including direct, and indirect evidence.
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subjects enteric nervous system
fecal transplant
gut microbiota
gut-brain axis
microbiota-targeted therapies
Neurology
parkinson's disease
title The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease
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