Effectiveness of preeclampsia prognosis in pregnancy

With the purpose to develop and assess the effectiveness of prediction method of pre-eclampsia (PE) 177 women in III trimester of pregnancy were examined. Of them: 133 women with preeclampsia of varying severity, 44 - with uncomplicated pregnancy. Prediction method is based on testing of thrombophil...

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Bibliographic Details
Published in:Medychni perspektyvy 2014-01, Vol.19 (1), p.101-106
Main Author: Loskutova, T O
Format: Article
Language:eng ; rus ; ukr
Subjects:
antiphospholipid antibodies
gene polymorphism
Health risk assessment
hemostasis
Maximum likelihood method
pre-eclampsia
Preeclampsia
Pregnancy
probability
prognosis
risk group
Womens health
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Summary:With the purpose to develop and assess the effectiveness of prediction method of pre-eclampsia (PE) 177 women in III trimester of pregnancy were examined. Of them: 133 women with preeclampsia of varying severity, 44 - with uncomplicated pregnancy. Prediction method is based on testing of thrombophilia genes, level of antibodies to β2 glycoprotein-1, D-dimer, value of atherogenicity coefficient. Using maximum likelihood method risk function was designed and formula which allows to estimatie probability of pre-eclampsia development was made. For practical applications, a graphical representation of likelihood of pre-eclampsia development from the calculated risk function is given. The sensitivity of the proposed model is 82,5% (95% CI 74,2-88,9%), specificity - 90,9% (95% CI 78,3-88,9%). To evaluate the effectiveness this prediction method was tested on a group of 108 pregnant women who were tested in the first trimester. 84 pregnant women were in the group with the predicted low risk (P(y)
ISSN:2307-0404
2307-0404
DOI:10.26641/2307-0404.2014.1.24703