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THE AMINO- AND CARBOXYL-TERMINAL RESIDUES AND THE SELF-DIGESTION OF BOVINE PANCREATIC CARBOXYPEPTIDASE A

The generic term carboxypeptidase A applies to an enzyme which can be prepared by three different procedures yielding preparations which differ from each other chemically in amino acid composition, in NH2-terminal residues, and in solubility. In the present study, the terminal amino acid residues of...

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Main Authors: Bargetzi, Jean-Pierre, Thompson, E O P, Kumar, K S V Sampath, Walsh, Kenneth A
Format: Report
Language:English
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Summary:The generic term carboxypeptidase A applies to an enzyme which can be prepared by three different procedures yielding preparations which differ from each other chemically in amino acid composition, in NH2-terminal residues, and in solubility. In the present study, the terminal amino acid residues of each of the preparations were identified. In addition, quantitative data are presented to demonstrate a hitherto undetected heterogeneity in the COOH-terminal region of these enzymes. This heterogeneity involves a single amino acid replacement which probably is an expression of a genetic trait. (Author) Reprint from the Jnl. of Biological Chemistry, 239:11, pp. 3767-3774, Nov 64. (Copies supplied by DDC)