PECULARITIES OF OVINE CELLS IN CULTURE

The chromosome complement of two ovine (Ovis aries L.) kidney cell lines are described. Nuclei of MDOK, the older cell line, are generally larger than those of OK cells, they are hypo-tetraploid and show considerable chromosomal irregularities both in structure and behavior. The OK line observed sin...

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Bibliographic Details
Main Authors: Nelson-Rees,Walter A, Kniazeff,Alexis J, Darby,Norman B. ,Jr
Format: Report
Language:English
Subjects:
BOVINES
CELLS(BIOLOGY)
CHROMOSOMES
GENETICS
KIDNEYS
MAMMALS
SEX
TISSUE CULTURE CELLS
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Summary:The chromosome complement of two ovine (Ovis aries L.) kidney cell lines are described. Nuclei of MDOK, the older cell line, are generally larger than those of OK cells, they are hypo-tetraploid and show considerable chromosomal irregularities both in structure and behavior. The OK line observed since its initiation, is now hyper-diploid and exhibits a gradual accumulation of chromosomes. Both cell lines have in common the fact that they now maintain a larger proportion of chromosomes with interstitial centromeres than telocentric chromosomes. This observation parallels similar ones made earlier in bovine cells. However, the processes whereby this condition arose in the respective cultures are believed to be different and are discussed. (Author) Pub. in Chromosoma v16 n1 p79-89 1965 (Copies available only to DDC users).