STUDIES ON THE HEMOGLOBIN-OXYGEN EQUILIBRIUM

Whole blood and hemolysate from a hemoglobin M(O) heterozygote showed a lower oxygen affinity than normal adult blood and hemolysate. A decreased heme-heme interaction was also observed in the hemolysate from the patient. Extent of hybridization between human adult and canine hemoglobins decreased w...

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Bibliographic Details
Main Author: Tyuma,Itiro
Format: Report
Language:English
Subjects:
Anatomy and Physiology
Biochemistry
CHROMATOGRAPHIC ANALYSIS
DOGS
ELECTROPHORESIS
EQUILIBRIUM(PHYSIOLOGY)
GENETICS
HEMOGLOBIN
HUMANS
HYBRIDS(BIOLOGY)
JAPAN
MACROMOLECULAR BIOLOGY
OXIDATION
OXYGEN
RATS
SPECTROSCOPY
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Summary:Whole blood and hemolysate from a hemoglobin M(O) heterozygote showed a lower oxygen affinity than normal adult blood and hemolysate. A decreased heme-heme interaction was also observed in the hemolysate from the patient. Extent of hybridization between human adult and canine hemoglobins decreased with the decrease of oxygen saturation of the pigments. A rough rectangular hyperbolic relation was noticed between the extent of hybridization and the degree of oxygenation. Heterogenous feature of chromaiographic fractions of rat hemoglobin was revealed on the starch-gel electrophoretic analysis of them. A simple and efficient apparatus was developed for concentrating any dilute macromolecule solution. (Author) See also AD-624 740.