EFFECTS OF PSYCHOPHARMACOLOGIC DRUGS UPON SENSORY INFLOW IN NORMAL SUBJECTS, IN PSYCHIATRIC PATIENTS AND IN ANIMALS

Averaged visual evoked potentials are being studied in man and animals by means of a computer of average transients (CAT). Modifications incorporated to this computer are described. Effects of psychotropic drugs upon the averaged visual evoked response (VER) in normal subjects are studied. LSD 25 de...

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Bibliographic Details
Main Author: Austt,Elio Garcia
Format: Report
Language:English
Subjects:
ANIMALS
CHLORPROMAZINE
ELECTROENCEPHALOGRAPHY
HUMANS
LYSERGIC ACIDS
Medicine and Medical Research
Pharmacology
PSYCHOPHARMACOLOGY
PSYCHOTROPIC AGENTS
RESPONSE(BIOLOGY)
SLEEP
STIMULATION(PHYSIOLOGY)
URUGUAY
VISION
VISUAL PERCEPTION
WAKEFULNESS
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Summary:Averaged visual evoked potentials are being studied in man and animals by means of a computer of average transients (CAT). Modifications incorporated to this computer are described. Effects of psychotropic drugs upon the averaged visual evoked response (VER) in normal subjects are studied. LSD 25 determined multiplication of the waves. The response amplitude increased during continuous flicker stimulation instead of decreasing as observed in controls. Chlorpromazine reduced VER amplitude both in wakefulness and sleep. Stupour and coma VER was simple, lower amplitude than normals. Stuporous subjects important changes were observed generally in conjunction with modifications in background activity indicative of changes in the level of awareness. Effects of same drugs upon visual inflow along primary and secondary visual pathways were studied in cats. LSD 25 VER changed in pattern as well as in amplitude. An increase in latency of secondary waves was evident. Chlorpromazine provoked an increase of primary response with small doses. Larger doses tended to decrease it and to reach normal amplitude. (Author)