A GENERALIZED HERPES VIRUS INFECTION IN OWL MONKEYS

The generalized viral disease caused by a herpes virus in owl monkeys (Aotus trivirgatus) is an acute fulminating disease that has been 100% fatal. The incubation period for all experimentally inoculated owl monkeys except the intracerebrally infected animal, which died in 3 days, ranged between 5 t...

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Bibliographic Details
Main Authors: Sheldon,Winslow G, Ross,Martin A
Format: Report
Language:English
Subjects:
Biology
BLOOD CHEMISTRY
DISEASES
HERPETIC VIRUSES
HISTOLOGY
INFECTIOUS DISEASES
Microbiology
MONKEYS
MORTALITY RATE
PATHOLOGY
VIRUS DISEASES
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Summary:The generalized viral disease caused by a herpes virus in owl monkeys (Aotus trivirgatus) is an acute fulminating disease that has been 100% fatal. The incubation period for all experimentally inoculated owl monkeys except the intracerebrally infected animal, which died in 3 days, ranged between 5 to 7 days and death occurred from 7 to 10 days after inoculation. Late in the course of the disease there is a moderate leukopenia that progresses to a terminal degenerative shift to the left; this is accompanied by anisocytosis, poikilocytosis, nucleated erythrocytes, and a moderate decrease in hemoglobin and packed cell volume. The most significant clinical change is the 3- to 10-fold increase in both SGOT and SGPT values. Pathologic changes are severe and affect primarily the liver, oral mucosa, adrenals, lymphoid tissue and skin, though lesions have been observed in other tissues, including the brain and kidney. A similarity of lesions to those seen in generalized herpes simplex virus disease of humans is suggested. (Author)