FLUOROMETRIC DETECTION OF BIOLOGICAL CHANGES IN IRRADIATED LABORATORY ANIMALS

The exposure of rats to either 80 or 230 rad of gamma irradiation from a Cobalt-60 source was found to effect the levels of certain fluorescent fractions excreted in urine. In addition to the changes in fluorometrically detectable fractions, an ultraviolet absorbing component, in urine, was found to...

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Bibliographic Details
Main Author: Demetriou,J. A
Format: Report
Language:English
Subjects:
BODY FLUIDS
BODY WEIGHT
CHROMATOGRAPHIC ANALYSIS
CREATININE
EXCRETION
FLUORESCENCE
RADIATION DOSAGE
RADIATION EFFECTS
Radiobiology
ULTRAVIOLET SPECTROSCOPY
URINE
WHOLE BODY IRRADIATION
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Summary:The exposure of rats to either 80 or 230 rad of gamma irradiation from a Cobalt-60 source was found to effect the levels of certain fluorescent fractions excreted in urine. In addition to the changes in fluorometrically detectable fractions, an ultraviolet absorbing component, in urine, was found to increase following 80 rad of whole body irradiation. The effects of radiation on body weights, creatinine and urine excretion were observed only at the 230 rad dose. Fluorometric, spectrophotometric, fractionation techniques of urine samples are described. (Author)