RADIOPROTECTION WITH 2-(1 DECYLAMINO) ETHANETHIOSULFURIC ACID IN THE RHESUS MONKEY

An attempt was made to provide radioprotection of the Macaca mulatta primates by the use of 2-(1 decylamino) ethanethiosulfuric acid, a long chain, lipid-soluble compound. The animals were divided into seven groups: two drug control groups, one radiation control group, and four treatment groups. Eac...

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Bibliographic Details
Main Authors: Paull, Robert M, Melville, George S , Jr
Format: Report
Language:English
Subjects:
AMINES
BIOPSY
DOSAGE
ETHANETHIOSULFURIC ACID/2-(1-DECYLAMINO)
MONKEYS
ORGANIC SULFUR COMPOUNDS
Pharmacology
RADIATION INJURIES
Radiobiology
RADIOPROTECTIVE AGENTS
SULFURIC ACID
SURVIVAL(PERSONNEL)
THIOLS
THIOSULFURIC ACIDS
TOXICITY
WHOLE BODY IRRADIATION
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Summary:An attempt was made to provide radioprotection of the Macaca mulatta primates by the use of 2-(1 decylamino) ethanethiosulfuric acid, a long chain, lipid-soluble compound. The animals were divided into seven groups: two drug control groups, one radiation control group, and four treatment groups. Each treatment group received a different dosage of drug or had a different latent period between administration of the drug and total-body irradiation. Clinical parameters were monitored and one animal from three of the treatment groups as well as two drug controls were necropsied and examined for signs of radiation damage or drug toxicity. Survival times were compared between treated animals and controls. Results indicate that this compound, given as described, does not afford the predicted degree of radioprotection.