USE OF IONIZING RADIATIONS FOR THE PREPARATION OF RADIO VACCINES AND RADIO-ANTIGENS

The possibility of employing ionizing radiations in certain doses to kill microorganisms was used to produce vaccines against intestinal infections and also to obtain from these bacteria antigens capable of being used as chemical vaccines. Typhoid fever and dysentery radiovaccines and radio-antigens...

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Bibliographic Details
Main Authors: Tumanyan, M A, Khrushchev, V G
Format: Report
Language:English
Subjects:
ANTIBODIES
ANTIGENS
ATTENUATION
BACTERIA
CULTURE MEDIA
FOREIGN REPORTS
GAMMA EMISSION
GERMICIDES
IMMUNITY
INFECTIOUS DISEASES
Microbiology
NUCLEAR RADIATION
PREPARATION
Protective Equipment
RADIATION DOSAGE
SALMONELLA TYPHOSA
SHIGELLA DYSENTERIAE
STERILIZATION
TOXICITY
TOXINS AND ANTITOXINS
TRANSLATIONS
USSR
VACCINES
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Summary:The possibility of employing ionizing radiations in certain doses to kill microorganisms was used to produce vaccines against intestinal infections and also to obtain from these bacteria antigens capable of being used as chemical vaccines. Typhoid fever and dysentery radiovaccines and radio-antigens were prepared and the effect of various gamma-ray doses on their toxicity and their antigenic and immunogenic properties was tested. The doses used did not change the properties of these products as compared with those of vaccines and antigens produced by conventional means. The paper also discusses the possibility of using radiation to sterilize the already prepared vaccines and antigens including radiovaccines and radio-antigens, anitoxins, antitoxic serums and nutrient media for the culture of microorganisms. Data on the irradiation apparatus used for these investigations are reported. Trans. of Proceedings of a Symposium, International Atomic Energy Agency, Vienna, p231-241, 1967.