Analysis of Antiparasitic Drugs in Fortified Dogfood

Procedures were developed for the extraction and quantitation of two antiparasitic drugs that are presently incorporated into military dogfood. Styrylpryidinium, a canine hookworm chemoprophylactic, was quantitated by ultraviolet spectroscopy. Diethylcarbamazine, an antiheartworm drug, was analyzed...

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Bibliographic Details
Main Authors: Criscuolo,Dominic, Casey,Harold W
Format: Report
Language:English
Subjects:
Animal Husbandry and Veterinary Medicine
ANTHELMINTICS
CHROMATOGRAPHIC ANALYSIS
DIET
DIETHYLCARBAMAZINE
DOGS
DOSAGE
DRUGS
FOOD
HEARTWORMS
HOOKWORMS
INGESTION(PHYSIOLOGY)
PARASITIC DISEASES
Pharmacology
QUANTITATIVE ANALYSIS
SPECTROSCOPY
STABILITY
TEMPERATURE
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Summary:Procedures were developed for the extraction and quantitation of two antiparasitic drugs that are presently incorporated into military dogfood. Styrylpryidinium, a canine hookworm chemoprophylactic, was quantitated by ultraviolet spectroscopy. Diethylcarbamazine, an antiheartworm drug, was analyzed by means of gas-liquid chromatography. The extraction and analytical procedures permitted the detection of both drugs to levels of less than 0.150 mg./gm. of food. (Author)