Further Characterization and Species Specificity of Leukocytic Endogenous Mediator (LEM) (36842)

A degree of cross species susceptibility was observed on the effects of leukocytic endogenous mediator (LEM) on serum zinc depression and amino acid flux. LEM was shown to be protein in nature, and relatively stable under a wider range of pH and conditions of storage. Although LEM shares several che...

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Bibliographic Details
Main Authors: Pekarek, R S, Wannemacher, Jr , R W, Chapple, III, F E, Powanda, M C, Beisel, W R
Format: Report
Language:English
Subjects:
AMINO ACIDS
Anatomy and Physiology
BIOCHEMISTRY
CHEMICAL PROPERTIES
INFECTIOUS DISEASES
LEUKOCYTES
METABOLISM
PHYSIOLOGY
PROTEINS
REPRINTS
ZINC
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Summary:A degree of cross species susceptibility was observed on the effects of leukocytic endogenous mediator (LEM) on serum zinc depression and amino acid flux. LEM was shown to be protein in nature, and relatively stable under a wider range of pH and conditions of storage. Although LEM shares several chemical and physical characteristics with endogenous pyrogen (EP), some differences between the chemical properties and species specificity of these two mediators were noted. Pub. in The Proceedings of the Society for Experimental Biology and Medicine, v141 n2 p643-648 Nov 1972.