Failure of Methylprednisolone to Protect Lead-Sensitized Rats against Endotoxin

The administration of lead acetate (PbAc2) sensitizes both rats and subhuman primates to minute amounts of bacterial endotoxin. The mechanism of this sensitization has not been defined, although it has been suggested that alterations in either the degradation of endotoxin, or in carbohydrate metabol...

Full description

Saved in:
Bibliographic Details
Main Authors: Jones, Robert B, Wise, James L, Kiesow, Lutz A
Format: Report
Language:English
Subjects:
BACTERIAL DISEASES
CORTICOSTEROID AGENTS
ENDOTOXINS
EXPERIMENTAL DATA
IMMUNOLOGY
INFECTIOUS DISEASES
LABORATORY ANIMALS
LEAD(METAL)
Medicine and Medical Research
METHYLPREDNISOLONE
SENSITIVITY
TOXINS AND ANTITOXINS
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The administration of lead acetate (PbAc2) sensitizes both rats and subhuman primates to minute amounts of bacterial endotoxin. The mechanism of this sensitization has not been defined, although it has been suggested that alterations in either the degradation of endotoxin, or in carbohydrate metabolism, may be important. Glucocorticoids are demonstrably effective in protecting normal animals against endotoxin. The purpose of the present investigation was to determine if this was also the case in lead-sensitized animals. Pub. in Infection and Immunity, v8 n4 p683-684 Oct 1973.