Toxicological Evaluation of Polyvinyl Acetate (PVA) Emulsion Dust Control Material, May 1973-March 1974

The relative toxicity of polyvinyl acetate (PVA) emulsion dust control material was investigated using laboratory animals. PVA emulsion is a mixture composed of a base latex plasticized with cresyl diphenyl phosphate (Santicizer 140) and tetraethylene glycol di-(2-ethylhexanoate) (Flexol 4G0). The P...

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Bibliographic Details
Main Authors: Weeks,Maurice H, Pope,Conrad R
Format: Report
Language:English
Subjects:
BIOASSAY
CHOLINESTERASE
DUST CONTROL
EMULSIONS
INGESTION(PHYSIOLOGY)
IRRITATING AGENTS
PERSONNEL
Polyvinyl acetate
SKIN(ANATOMY)
Toxicology
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Summary:The relative toxicity of polyvinyl acetate (PVA) emulsion dust control material was investigated using laboratory animals. PVA emulsion is a mixture composed of a base latex plasticized with cresyl diphenyl phosphate (Santicizer 140) and tetraethylene glycol di-(2-ethylhexanoate) (Flexol 4G0). The PVA emulsion, base latex, and Flexol 4G0 produced moderate to severe primary irritation when applied to the intact and abraded skin of rabbits. Santicizer 140 did not produce eye or skin irritation but did cause a reduction in blood plasma cholinesterase activity of squirrel monkeys and coturnix quail 24 hours after a single intraperitoneal injection. Data indicate little acute toxic hazard from ingestion of PVA emulsion or its component compounds. No clinical significant changes occurred in groups of dogs or rats as a result of repeated exposures to aerosols of PVA emulsion. (Modified author abstract)