Experimental Study of the Effect of the Dose of a Chemical Substance on the Incidence and Intensity of Contact Allergy

A direct relationship exists between the dose of a chemical allergen and the intensity of contact allergy. In a large number of chemical allergens, the threshold of allergizing action is below the threshold of toxic action during absorption through the skin. On this basis when setting permissible st...

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Bibliographic Details
Main Authors: Alekseeva,O. G, Barlogova,S. G, Dueva,L. A, Zagidullin,Sh. Z, Raben,A. S
Format: Report
Language:English
Subjects:
Allergens
Allergic diseases
Antigens
Chemical agents
Contact dermatitis
Dermatitis
Dosage
Environmental Health and Safety
Immunology
Industrial medicine
Medicine and Medical Research
Skin(Anatomy)
Thresholds(Physiology)
Toxicity
Translations
USSR
Online Access:Request full text
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Description
Summary:A direct relationship exists between the dose of a chemical allergen and the intensity of contact allergy. In a large number of chemical allergens, the threshold of allergizing action is below the threshold of toxic action during absorption through the skin. On this basis when setting permissible standards it is not necessary to consider the specific effect. Certain weak allergens can be active sensitizers even in toxic doses.