IMMUNOLOGICAL RESEARCH ON BASIC SPECIFIC AND NON-SPECIFIC PROTEIN ANTIGENS OF THE TYPE STREPTOCOCCUS PYOGENES (GROUP A)

Immunoelectrophoresis and electrophoresis have confirmed that acid- alcohol gamma extracts contained several type specific and non-specific protein antigens which were basic proteins. Their isoelectric point is above 8.5, while that of the non-type specific proteins was higher than that of the M pro...

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Bibliographic Details
Main Authors: Wahl, R, Goichot, J, Drach, G
Format: Report
Language:English
Subjects:
ANTIBODIES
ANTIGENS
BACTERIAL EXTRACTS
ELECTROPHORESIS
FOREIGN REPORTS
FRANCE
IMMUNE SERUMS
Microbiology
NUCLEIC ACIDS
PH FACTOR
POLYSACCHARIDES
STREPTOCOCCUS PYOGENES
TRANSLATIONS
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Summary:Immunoelectrophoresis and electrophoresis have confirmed that acid- alcohol gamma extracts contained several type specific and non-specific protein antigens which were basic proteins. Their isoelectric point is above 8.5, while that of the non-type specific proteins was higher than that of the M protein. They showed that the isoelectric point of M protein (about pH 9) extracted by the acid-alcohol method is very much greater than that of M protein extracted by the Lancefield method. This difference appears to indicate that the M protein is found in different states in the two extracts. In contrast, the migration of the non-type specific antigens is the same in the gamma and Lancefield extracts. Immunoelectrophoresis showed that the III alpha fraction, which is responsible for the retarded allergy, contains several antigens or several antigenic determinants. Trans. of Institut Pasteur, Paris. Annales (France) n109 p479-486, 1965.