Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis

We report the synthesis and characterization of a water-stable zirconium metal-organic framework(MOF), NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase (OPAA)....

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Bibliographic Details
Main Authors: Li,Peng, Moon,Su-Young, Guelta,Mark A, Lin,Lu, Gomez-Gualdron,Diego A, Snurr,Randall Q, Harvey,Steven P, Hupp,Joseph T, Farha,Omar K
Format: Report
Language:English
Subjects:
enzyme immobilization
Enzymes
hydrolysis
mof(metal-organic framework)
nanocarrier
NANOMATERIALS
NANOMEDICINE
nerve agent catalysis
nerve agents
nu-1003
Zirconium compounds
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Summary:We report the synthesis and characterization of a water-stable zirconium metal-organic framework(MOF), NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase (OPAA). The catalytic efficiency of immobilized OPAA in nanosized NU-1003 is significantly increased compared to that of OPAA immobilized in microsized NU-1003 and even exceeds that of the free OPAA enzyme. This paper highlights a method for rapid and highly efficient hydrolysis of nerve agents using nanosized enzyme carriers. ACS Nano , 10, 10, 01 Jan 0001, 01 Jan 0001, Open Access: Publishers Version. May be placed on public websites; ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.