Safety Parameter Considerations of Anodal Transcranial Direct Current Stimulation in Rats

A commonly referenced transcranial Direct Current Stimulation (tDCS) safety threshold derives from tDCS lesion studies in the rat and relies on electrode current density (and related electrode charge density) to support clinical guidelines. Concerns about the role of polarity (e.g., anodal tDCS), su...

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Bibliographic Details
Main Authors: McKinley,R A, Jankord,Ryan, Jackson,Mark P, Truong,Dennis, Bikson,Marom, Brownlow,Milene L, Wagner,Jessica A
Format: Report
Language:English
Subjects:
brain
computational modeling
current density
direct current
Direct Current Stimulation
electrodes
Medicine and Medical Research
Microglia
rat cortex
statistical analysis
tDCS modeling
transcranial Direct Current Stimulation (tDCS)
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Summary:A commonly referenced transcranial Direct Current Stimulation (tDCS) safety threshold derives from tDCS lesion studies in the rat and relies on electrode current density (and related electrode charge density) to support clinical guidelines. Concerns about the role of polarity (e.g., anodal tDCS), sub-lesion threshold injury (e.g., neuroinflammatory processes), and role of electrode montage across rodent and human studies support further investigation into animal models of tDCS safety.