Porcine Burn Shock - Development of a Reliable Model and Response to Sodium, Water, and Plasma Loads Administered for Resuscitation

Minature swine are a sensitive and responsive animal for the study of burn shock resuscitation. The sodium loads requisite for resuscitation of burned swine can exert roughly the same effects when administered in volumes of from 25% to 50% less than those commonly employed clinically. Sodium excreti...

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Bibliographic Details
Main Authors: Wachtel, Thomas L, McCahan, Jr, G R
Format: Report
Language:English
Subjects:
ANIMAL MODELS
BODY FLUIDS
BURNS(INJURIES)
EXCRETION
EXPERIMENTAL DATA
LABORATORY ANIMALS
Medicine and Medical Research
PARENTERAL INFUSIONS
RESPONSE(BIOLOGY)
RESUSCITATION
SHOCK(PATHOLOGY)
SODIUM
STRESS(PHYSIOLOGY)
SWINE
THERAPY
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Summary:Minature swine are a sensitive and responsive animal for the study of burn shock resuscitation. The sodium loads requisite for resuscitation of burned swine can exert roughly the same effects when administered in volumes of from 25% to 50% less than those commonly employed clinically. Sodium excretion is more dependent upon the sodium load than upon the concentration of the saline solution. Plasma administration had no demonstrable resuscitative effect over and above that provided by the sodium and volume given in this model.