Hazard Evaluation of Candidate Face Net Impregnant Ent-8118-Gd Tetrahydrofurfuryl Octanoate Study

A hazard evaluation of the candidate face net impregnant tetrahydrofurfuryl octanoate (ENT-8118-Gd) was performed by means of laboratory animal studies using rats and rabbits. The technical grade compound produced very slight erythema when applied to the intact or abraded skin of rabbits. No corneal...

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Bibliographic Details
Main Authors: Weeks,Maurice H, Pope,Conrad R
Format: Report
Language:English
Subjects:
BIOASSAY
EYE
IMPREGNATION
INGESTION(PHYSIOLOGY)
INHALATION
IRRITATING AGENTS
LETHAL DOSAGE
NETS
OCTANOIC ACID
Octanoic acid/(tetrahydrofurfuryl-ester)
PERMISSIBLE DOSAGE
RABBITS
RATS
Recommendations
REPELLENTS
SKIN(ANATOMY)
Toxicology
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Summary:A hazard evaluation of the candidate face net impregnant tetrahydrofurfuryl octanoate (ENT-8118-Gd) was performed by means of laboratory animal studies using rats and rabbits. The technical grade compound produced very slight erythema when applied to the intact or abraded skin of rabbits. No corneal injury, iritis or conjunctivitis was observed after a single application of the technical grade compound to the eyes of rabbits. Data indicate little acute toxic hazard from accidental ingestion. Acute aerosol, anc acute and subchronic saturated vapor inhalation exposures of rats resulted experimentally in no deleterious effect. It is recommended that ENT-8118-Gd be approved for testing as a candidate face net impregnant.