Laboratory Studies on Viral Hepatitis

A large number of tissue cultures were evaluated for the isolation of hepatitis virus(es) from clinical specimens obtained from civilian and military cases of hepatitis. The most promising cell systems, Detroit-6 and human embryonic lung, were exhaustively studied but lack of reproducibility hindere...

Full description

Saved in:
Bibliographic Details
Main Authors: Brackett,Robert G, McLean,I William, Rightsel,Wilton A, Shillis,Joan L, Taylor,Alton R
Format: Report
Language:English
Subjects:
HEPATITIS VIRUSES
IDENTIFICATION
ISOLATION
LABORATORY TESTS
Microbiology
SEROLOGY
TISSUE CULTURE CELLS
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A large number of tissue cultures were evaluated for the isolation of hepatitis virus(es) from clinical specimens obtained from civilian and military cases of hepatitis. The most promising cell systems, Detroit-6 and human embryonic lung, were exhaustively studied but lack of reproducibility hindered efforts to develop a means for the routine isolation, propagation, and characterization of any of the isolates. Extensive searches for a serologic method to demonstrate specific antibody to these viruses also were unsuccessful. For these reasons, no conclusions could be drawn regarding the interrelationship between current isolates and the prototype agents which appeared to produce clinical hepatitis in earlier studies in volunteers.