Isolation of Protective Antigens from Plasmodium Falciparum

The elaboration of an in vitro test for protective malarial antibody has provided a means for assaying extracts from the simian parasite, Plasmodium knowlesi, for protective antigen activity. The purpose of the present work was to set up a similar short-term culture system for the human parasite Pla...

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Bibliographic Details
Main Authors: Cohen,S, Butcher,G A, Mitchell,G H
Format: Report
Language:English
Subjects:
ANTIGENS
CULTURES(BIOLOGY)
ERYTHROCYTES
IMMUNITY
IN VITRO ANALYSIS
MALARIA
Microbiology
MONKEYS
PARASITES
PARASITIC DISEASES
PLASMODIUM
Plasmodium falciparum
UNITED KINGDOM
VACCINES
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Summary:The elaboration of an in vitro test for protective malarial antibody has provided a means for assaying extracts from the simian parasite, Plasmodium knowlesi, for protective antigen activity. The purpose of the present work was to set up a similar short-term culture system for the human parasite Plasmodium falciparum which would permit the identification and isolation of protective antigens from this species of malaria. The ultimate objective of the work was to test the effectiveness of these preparations when used as vaccines against erythrocytic infections of P.falciparum in Aotus monkeys. During the initial year attention was directed towards setting up a method of short term in vitro culture of P.falciparum. During the second year the in vitro action of human immune sera on P.falciparum was studied. This in vitro system would provide a suitable means for the identification and isolation of protective antigens from P.falciparum. See also report dated Jan 74, AD-774 438.