Role of Mycoplasma Membranes in the Pathogenesis of Primary Atypical Pneumonia

The cold-agglutinin form of atypical pneumonia is caused by Mycoplasma pneumonia. The current study was designed to yield information on the mechanism of pathogenesis in this disease. Organisms were collected and membrane fractions were prepared. When membranes were evaluated for cytotoxic potential...

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Bibliographic Details
Main Author: Gabridge,Michael G
Format: Report
Language:English
Subjects:
CELLS(BIOLOGY)
CYTOTOXINS
HISTOLOGY
IN VIVO ANALYSIS
MEMBRANES(BIOLOGY)
Microbiology
MYCOPLASMA
Mycoplasma pneumoniae
NECROSIS
PATHOGENESIS
PNEUMONIA
RESPIRATORY DISEASES
TISSUE CULTURE
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Summary:The cold-agglutinin form of atypical pneumonia is caused by Mycoplasma pneumonia. The current study was designed to yield information on the mechanism of pathogenesis in this disease. Organisms were collected and membrane fractions were prepared. When membranes were evaluated for cytotoxic potential in the hamster tracheal ring/organ culture system, they displayed active biological activity. The necrosis induced in the ciliated respiratory epithelium was grossly equivalent to that induced by viable cells, and was dose-dependent. Cytotoxicity, as evaluated by histopathology and scanning electron microscopy, was essentially identical when damage caused by viable cells and membrane preparations were compared. See also report AD-768 864, dated October 1973.