Cardiophysiological Studies with Stressed Animals

The report presents data that show trifluoro-chloromethane (F-11) is more toxic to cardiomyopathic hamsters than to random-bred hamsters, and that the toxicity is qualitatively different as well. It was also shown in another species that the arrhymic potential of F-11 is increased by hypoxia and the...

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Bibliographic Details
Main Authors: Drew,Robert T, Taylor,George J
Format: Report
Language:English
Subjects:
ARRHYTHMIA
CARDIOLOGY
CARDIOVASCULAR SYSTEM
EXPERIMENTAL DATA
EXPOSURE(PHYSIOLOGY)
HAMSTERS
HEART
HYPOXIA
LABORATORY ANIMALS
Methane/chloro-trifluoro
PATHOLOGY
PHYSIOLOGICAL EFFECTS
PROPELLANTS
RABBITS
RESPONSE(BIOLOGY)
Stress Physiology
Toxicology
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Summary:The report presents data that show trifluoro-chloromethane (F-11) is more toxic to cardiomyopathic hamsters than to random-bred hamsters, and that the toxicity is qualitatively different as well. It was also shown in another species that the arrhymic potential of F-11 is increased by hypoxia and the arrhythmias observed are not the result of hypoxia alone. The data from these animal studies are not directly applicable to humans. Genetic cardiomyopathy is not presented as a model of human heart disease or even human cardiomyopathy. The acute hypoxia induced in rabbits is not representative of the acute hypoxic state of the patient with diseases such as asthma or respiratory failure. These data show only that animals with depressed physiologic reserve were more sensitive to F-11 than normal animals. Prepared in cooperation with National Inst. of Environmental Health Sciences, Research Triangle Park, N.C.